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GMS6540 - Final Exam Questions and Answers 2024
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GMS6540 - Final Exam
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GMS6540 - Final Examgenetic changes are required for which of the following to occur? - answer initiation/transformation of a cell
formation of a malignant tumor from a neoplastic lesion
formation of clinical cancer from a malignant tumor
metastasis of a clinical cancer
what effect would a G12V mutation in Ras have on ERK? - answer lead to increased
activation of ERK
Are cancers more likely to develop mutation that activate or inactivate Rb? - answer inactivate
metabolites of nicotine commonly result in DNA point mutations. which type of DNA instability is this an example of? - answer genetic instability
if a human cell underwent endoreduplication followed by failed cytokinesis, how many chromosomes would you expect that cell to now contain? - answer 184
which of the following statements is true regarding apoptosis? - answer cancer cells must avoid it.
which statement best describes the warburg effect? - answer switching of cancer cells from oxidative phosphorylation to aerobic glycolysis?
a pt. undergoes an FdG-PET scan. will tumor contain more or less 18-
fluorodeoxyglucose than normal the surrounding tissue? - answer more
angiogenesis is - answer the process of creating new blood vessels from current blood vessels
is inflammation harmful or beneficial to cancer? - answer beneficial
if a cell expressed a mutant form of EGFR, would this be considered a tumor specific antigen or a tumor associated antigen? - answer tumor specific antigen
describe how the cancer cells overcome the Hayflick limit? - answer upregulate telomerase what chemical causes the most cigarette-related DNA mutations? - answer benzo[a]pyrene
teh epstein-barr virus, famous for causing mononucleosis, also plays a prevalent role in the formation of what type of cancer? - answer burkitt's lymphoma
what viral protein is capable of inhibiting p53? - answer E6
which class of cancer drugs is the least selective towards cancer cells? - answer chemotherapy
is chemotherapy generally more effective when tumors are small or large? - answer small
summarize the treatment ramifications of the Goldie-Coldman hypothesis? - answer cancers must be treated w/ more than one drug
does drug resistance increase or decrease the therapeutic index of cancer drugs? - answer decrease
an inhibitor of what enzyme would be expected to increase the sensitivity of cancer cells
to vincristine? - answer MDR
Based on their toxicity profiles, what drug is likely to be excluded from use to treat lung cancer? - answer Bleomycin
what is the shared target of cyclophosphamide and cisplatin? - answer DNA
Does paclitaxel increase or decrease the amount of microtubules in cells? - answer increase
methotrexate targets cells in which phases of the cell cycle? - answer S
what is the most direct target of 5-FU? - answer Thymidaylate synthetase
cytosine arabinoside directly prevents the formation of - answer DNA
What is the basis for the selectively of Gleevec towards cancer cells? - answer cancer cells contain the Philadelphia chromosome
what is the target of pembrolizumab? - answer PD-1 on T-cells
which cells will CTL019 kill? - answer cancer cells expressing CD19
normal cells expressing CD19
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