Summary
samenvatting stofwisseling & hormonen
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samenvatting van diabetes, fysiologie van pancreas, fysiologie van hypothalamus & hypofyse
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SAMENVATTING STOFWISSELING& HORMONEN
GROEIHORMOON (FYSIOLOGIE & FYSIOPATHOLOGIE)
SYNTHESE & SECRETIE VAN GH
o Adenohypofyse
Gesyntheseerd door somatrotrope cellen
Pulsatief & varieert minuut tot minuut
Piekt tijdens slow-wave slaap
Per 24 uur 10 pulsen per 90 minuten
Leeftijdafhankelijk (meest bij puberteit)
GHRH (HYPOTHALAMO-HYPOFYSAIR-GROEIHORMOON)
o Gestimuleerd
Catecholaminen
Oestradiol, progesteron
Stress
Diepe slaap
Serotonine
ADH
Ghreline
o Geïnhibeerd
IGF-1 of somatomedine (lever)
Groeihormoon
Morfine
REM slaap
! GHRH stimuleert & somastatine inhibeert release van
GH !
o GHEH Secretie door neurosecretoire cellen van
nucleus arcuatus
o Somatostatine secretie in periventriculaire
nucleus
o GHRH stimuleert
Gentranscriptie, synthese van GH
Proliferatie van somatotrope cellen
! somatostatine domineert over GHRH !
CONTROLE GH
o Negatieve feedback
GH zelf
IGF-1 (van lever, nier, spier, kraakbeen, bot (paracrien of autocrien)
Thv hypofyse inhibeert IGF-1 de GH secretie
, Onderdrukt release van GHRH
Stimuleert secretie somatostatine
WERKING GH
o Acute effecten
Stimulatie lipolyse
Stimulatie gluconeogenen vnan
hepatocyten
Inductie insulineresistentie spieren, lever,
adipocyt
o Lange termijn
Plasmaspiegel IGF-1 stabiel (door binding
IGF-1 receptor)
o Anabool effect
Stimulatie groei bij kinderen
Stimulatie chrondocyten & osteoblasten
door IGF-1
o Overige effect:
IGF-1
Calciumretentie: meer botmineralisatie
Spiermassie neemt toe
Groei van organen (buiten hersenen)
Stimulatie immuunsysteem
Stimulatie renine, aldosteron, T3 productie
IGF-1 onafhankelijk
Erythropoïse
Insulinogenense
Gluconeogenese stijgt
Lipolyse stijgt
Meer opname AZ in cellen (meer eiwitsynthese)
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