Interorgan and Intracellular
Coordination of Energy
Metabolism in Vertebrates 556
17.1 Interdependence of the
Major Organs in Vertebrate
Fuel Metabolism 558
Fuel Inputs and Outputs 558
Metabolic Division of Labor Among the Major Organs
558
Brain 558
Muscle 560
Heart 560
Adipose Tis...
Biochemistr
C O N C EP TS AN D C O N N EC T I O N S
SECOND EDITION
Dean R. Appling
THE UNIVERSITY OF TEXAS AT AUSTIN
Spencer J. Anthony-Cahill
WESTERN WASHINGTON UNIVERSITY
Christopher K. Mathews
OREGON STATE UNIVERSITY
330 Hudson Street, New York, NY 10013
A01_APPL1621_02_SE_FM.indd 1
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Credit: The Human
Spliceosome
Dr. Berthold Kastner, Max
Planck lnstitute of
Biophysical Chemisty
Molecular graphics
and analyses were
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Chimpanzee Photo Credit: Fiona Rogers/Getty
Acknowledgments of third-party content appear on pages C-1–C-3, which constitutes an extension of this
copyright page.
PEARSON, ALWAYS LEARNING, MasteringTM Chemistry, and Learning Catalytics are exclusive
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Library of Congress Cataloging-in-Publication Data
Names: Appling, Dean Ramsay, author. | Anthony-Cahill, Spencer J., author. |
Mathews, Christopher K., 1937- author.
Title: Biochemistry : concepts and connections / Dean R. Appling, Spencer J.
Anthony-Cahill, Christopher K. Mathews.
Description: Second edition. | New York : Pearson, [2019] | Includes
bibliographical references and index.
Identifiers: LCCN 2017047599| ISBN 9780134641621 | ISBN 0134641620
Subjects: | MESH: Biochemical Phenomena
Classification: LCC RB112.5 | NLM QU 34 | DDC 612/.015--
dc23 LC record available at https://lccn.loc.gov/2017047599
[ Third-Party Trademark] [TM/®] is a [registered] trademark of [Third Party]. Used under
license. 1 18
ISBN 10: 0-134-64162-0; ISBN 13: 978-0-134-64162-1
www.pearson.com
A01_APPL1621_02_SE_FM.indd 3
, Brief Contents
1 Biochemistry and the Language 16 Lipid Metabolism 512
of Chemistry 2
2 The Chemical Foundation of Life:
Weak 17 Interorgan and Intracellula
Interactions in an Aqueous Environment Metabolism in Vertebrates
18
18 Amino Acid and Nitrogen
3 The Energetics of Life 48
19 Nucleotide Metabolism 61
4 Nucleic Acids 72
20 Mechanisms of Signal Tra
5 Introduction to Proteins: The Primary
Level of Protein Structure 108 6 The Three-
21 Genes, Genomes, and Ch
Dimensional Structure of Proteins 144 22 DNA Replication 686 23
Recombination, and Rear
7 Protein Function and Evolution 190
Transcription and Posttran
8 Enzymes: Biological Catalysts 232 742
9 Carbohydrates: Sugars, 25 Information Decoding: Tra
Saccharides, Posttranslational Protein P
Glycans 278 10 Lipids,
Membranes, and Cellular 26 Regulation of Gene Expre
Transport 304
APPENDIX I: ANSWERS TO SELECTED
11 Chemical Logic of Metabolism 340 A-1
12 Carbohydrate Metabolism: Glycolysis, APPENDIX II: REFERENCES A-20
Gluconeogenesis, Glycogen Metabolism, CREDITS C-1
and the Pentose Phosphate Pathway 374
INDEX I-1
13 The Citric Acid Cycle 420
14 Electron Transport,
Oxidative
Phosphorylation, and Oxygen
Metabolism 450
15 Photosynthesis 486
A01_APPL1621_02_SE_FM.indd 4
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