BIOL 2200 PATHOPHYSIOLOGY: CASE STUDY 1/2 REVIEW RATED A+

BIOL 2200 PATHOPHYSIOLOGY: CASE STUDY 1/2 REVIEW RATED A+ Explain the 3 plasma protein systems of the chemical portion of inflammation 1. Clotting proteins: Cascade reactions that activate proteins which produces fibrin net that traps pathogens and forms a clot. 2. Complement System: Cascade reactions that activate proteins which kills pathogens directly or intensify reactions of other components of the inflammatory response = very strong defenders against bacterial infection 3. Kinin System: Cascade reactions that activate proteins which assist with inflammatory response. Major kinin is bradykinin which causes increased permeability and acts with other compounds to produce pain. IL-1 Interleukin- 1 Produced by tissue macrophages. Responds to bacterial endotoxin and tissue damage. Helps neutrophils migrate to site of inflammation Stimulates acute phase reaction: fever & loss of appetite Causes epithelial cells to produce other cytokines (IL8) TNF Tumour Necrosing Factor Produced by macrophages Released particularly in response to bacterial antigens & IL1 Helps neutrophils migrate to site of inflammation Stimulates acute phase reaction IL-6 Produced by macrophages Stimulates the liver to produce chemicals that induce the acute phase response IL-8 Produced by macrophages Potent neutrophil chemokine (brings wbc to infection) TGF-BETA Transforming Growth Factor- Beta Released by macrophages and platelets Attracts phagocytes and fibroblasts and is very important in the healing process Prostaglandins Produced from a long chain fatty acid Induces vasodilation and brochoconstriction inhibits