Summary
Summary stroke
- Course
- Institution
ischaemia and haemorrhagic stroke
[Show more]
Seller
Follow
rosiemalley
Reviews received
Content preview
StrokeWhat is an ischemic stroke?
more common
80% strokes
blood clot supply disrupted
a clot or plaque is the cause
causing atherosclerosis
Causes of ischaemic stroke
cerebral thrombosis from atherosclerosis (atherosclerosis, fatty deposits causing a
plaque, sticks and becomes a clot in a vessel)
distal embolism from cardioembolic disease (e.g. AF where a clot forms in the heart
and travels to the brain and causes an occlusion)
How do we treat ischaemic stroke?
alteplase
o tissue plasminogen activator
o has a thrombolytic effect
o must be given within 4.5 hr
o otherwise, won’t be as effective
What is a haemorrhagic stroke?
less common
bleeding into the brain
Cause of haemorrhagic stoke
depends on where the bleed is
intracerebral haemorrhage (rupture small vessel in brain)
Subarachnoid haemorrhage (rupture of intracranial aneurysm in the subarachnoid
space, lining of the brain)
How do we treat haemorrhagic stroke?
surgery: craniotomy
repair the blood vessel
clot removal
manage blood pressure:
o reduces blood flow to the brain
o ACE inhibitors
o beta blockers
o lifestyle changes-diet and exercise
What is a TIA?
transient ischaemic attack
symptoms of stroke that resolve within 24 hours
Pathophysiology behind a stroke
cells are deprived of nutrients and oxygen
leading to cell death and brain damage
umbra: area of irrecoverable damage
penumbra: area of potential recovery
in stroke cytokine interleukin-1Beta is produced
o leads to brain inflammation
o exacerbates the brain damage
, o a pro-inflammatory cytokine
Following a stroke:
interleukin 1 beta binds to interleukin 1 receptor on nearby cells
o e.g. endothelial, neural cells
triggers intracellular signalling pathways
including the activation of transcription factor nuclear factor kappa B (NFkB)
This activation prompts the translocation of IL-1β into the cell and ultimately into the
nucleus.
IL-1β acts as a transcription factor, influencing the expression of various genes
involved in inflammation and immune response regulation.
One of the genes activated by IL-1β is that encoding interleukin 6 (IL-6).
IL-6 is a pro-inflammatory cytokine that plays a significant role in the acute phase
response to injury or infection. It promotes inflammation and recruits immune cells
to the site of injury.
further amplifies the inflammatory response within the brain tissue.
IL-1β can also induce the production of tumour necrosis factor-alpha (TNF-α),
another pro-inflammatory cytokine exacerbating a stroke
How do we treat a stroke? Pathophysiology behind treatment
interleukin-1 receptor antagonist
this reduces the infarct volume
o volume or size of the area of tissue in an organ that has undergone infarction
o resulting in tissue death and unoxygenated blood supply to the area
How do we diagnose a stroke?
droopy face, speech, lose power down one side
might not be a stroke that causes these symptoms
but investigate to exclude stroke first
this is a medical emergency
look for other causes
Examples of conditions that can cause a stroke
e.g. seizures
drug toxicity (e.g. overdose)
brain tumour
migraine
spinal cord lesion
Risk factors of stroke
age
o risk doubles with every decade over age 55
gender
o men at higher risk (more common)
o but more women die of stroke
family history
Afro-Caribbean ethnicity
o e.g. risk of other conditions, sickle cell, diabetes etc
hypertension
o modifiable as antihypertensives reduce incidence by 40%
o treat it to reduce risk
AF
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller rosiemalley. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.98. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
80461 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now