Summary
Patches summary
- Course
- Institution
summary of the types of patches and components
[Show more]
Seller
Follow
rosiemalley
Reviews received
Content preview
PatchesFunctions of the skin
- designed to keep xenobiotics (chemical foreign substance) and micro-organisms out
of the body
- contains nerve endings to detect touch, pressure, temperature and pain
- sweat lands to eliminate waste and maintain electrolyte balance
- blood supply
- sweat: thermoregulation
What is the stratum corneum?
Outermost layer of epidermis
Top layer of skin
Dead, flattened skin cells surrounded bu lipids
Serves as a barrier to protect from pathogens, chemicals and UV radiation
Paracellular vs transcellular routes
Transcellular:
- hydrophilic drugs
- penetrates the aqueous regions of keratin filaments
Paracellular:
- most drugs and lipid molecules
- stays in lipid bilayers disrupting lipid regions
- pass between the cells
Topical vs transdermal
topical: only local, the top layers of the skin
transdermal: fooling the stratum corneum to allow drugs into the skin
Passive vs active transdermal delivery
Passive:
diffusion of a drug
constant diffusion rate
depends on skin and patch characteristics
Active:
using a method to aid transfer
e.g. physical (microneedles)
or electrically assisted methods (iontophoresis)
Types of passive transdermal patches
Matrix
Reservoir
Drug in adhesive
Advantages of passive transdermal patches
painless
non invasive
controlled blood levels
termination possible by removing patch easily
less inconvenience e.g. IV administration
vomiting/diarrhoea/coma patients unable to take oral medication
avoidance of the GIT-no 1st pass metabolism, food effects, intestinal degradation, etc
increased patient compliance
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller rosiemalley. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.92. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
81113 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now