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Biomedicine 1 - Lecture Notes neurotransmission $12.38   Add to cart
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Biomedicine 1 - Lecture Notes neurotransmission

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  • Course
  • Dental Hygiene and Therapy
  • Institution
  • Kings College London (KCL)

Accurate and concise lecture notes on neurotransmission in dental treatments. Includes coloured diagrams and images Thorough explanations and definitions of key terms.

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Document information

  • May 23, 2024
  • 6
  • 2023/2024
  • Class notes
  • N/a
  • All classes

Subjects

  • biomedicine
  • dentistry
  • dental hygiene
  • dental therapy
  • nursing
  • healthcare
  • science
  • biology
  • chemistry
  • nervous sytem
  • dental treatments

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  • Kings College London (KCL)
  • Unknown
  • Dental Hygiene and Therapy
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Lesson 3: Neurotransmission in dental treatments

- Specialised sensory nerves called nociceptors detect tissue damage.
- Triggers action potentials which propagate along the sensory neuron to the brain via
the spinal cord an synapses
- Local anaesthetics stop action potentials to prevent pain
- Their molecular target are voltage gated sodium ion channels
- The drug blocks the channel pore and prevents entry of sodium ions and the initiation
of an action potential
- Life threatening effects are minimised by applying drugs to a localised region
- The local conc of an anaesthetic required to block the action potential in a sensory
nerve is 0.1 - 1mM. The lethal systemic plasma conc is 40-60 micrometres

Anaesthesia
- Local anaesthetic molecules consist of an aromatic head linked to a basic side chain
by an amide or an ester bond
- Those with ester bonds are destroyed by hydrolysis
- Local anaesthetic are weak bases with a pka value of 8
- At physiological ph the drugs exist both in their ionised and unionised form

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