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NR_546_Ford_Week_6_Table.docx
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NR 546Week 6 Addiction Medication Table
Dwayne Ford 8/23
Drug Name Indication Half-life (T1/2), Notable Side Effects Initial Dosing Considerations
Neurotransmitter(s) Metabolism (CYP (link to NT or Specific lifespan
Affected 450 enzyme) affected brain circuit) considerations (age,
Target Symptoms pregnancy, breastfeeding)
Buprenorphine Indication: Treatment Subutex half-life Activates opioid - use for 16 years and older
(Subutex) of opioid addiction and 38 hours, receptors, primarily
opioid dependence the mu-opioid -safe for both pregnant and
Target Symptoms: Pain Cytochrome P450 receptor, which can breastfeeding women.
relief, reduced cravings, 3A4/3A5- lead to constipation,
and improved quality of mediated N- nausea, drowsiness,
life. dealkylation dizziness, itching,
Affected and vomiting.
Neurotransmitters:
Activates opioid
receptors, primarily the
mu-opioid
receptor.
Buprenorphine/Naloxone Indication: Treatment Suboxone, Activates opioid -use for 16 years and older
(Suboxone, Zubsolv, of opioid addiction and Zubsolv, 24 to 42 receptors, primarily
[Bunavail-no longer opioid dependence. hours the mu-opioid -safe for both pregnant and
available as of March 2020]) Target Symptoms: Pain receptor, which can breastfeeding women.
relief, reduced cravings, Bunavail, 16.4 to lead to constipation,
and improved quality of 27.5 hours. nausea, drowsiness,
life. dizziness, itching,
Affected Cytochrome P450 and vomiting.
Neurotransmitters: 3A4 (CYP3A4)
Activates opioid enzyme
receptors, primarily the
mu-opioid receptor.
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