Chemotherapy Certification questions
with correct answers
Doxorubicin - answer-Cardiotoxic
TISSUE VESICANT
Baseline MUGA and total dose (CONCERN at 550 mg/m2)
URINE=RED
IF EXTRAVASATION OCCURS= cool/ice + Totect
Idamycin - answer-Cardiotoxic (cardiomyopathy)
Bleomycin - answer-AVOID oxygen supplementation
Methotrexate - answer-*Leukovorin decreases cytotoxicity*
Pemetrexed - answer-Vitamin B12 & folic acid supplements to decrease toxicity
Fludarabine - answer-Immunosuppression
Thioguanine - answer-Bone Marrow Suppression
Stomatitis/Mucositis
5-FU - answer-*Stomatitis
Bone marrow depression
*Diarrhea
Mucositis
Capeticibine - answer-***Pro-drug that converts 5FU in liver
Stomatitis & mucositis
Palmar-plantar erythrodysthesias (hand foot syndrome)
Cytarabine or Cytosine Arabinoside - answer-Cerebellar neurotoxicity
, Gemcitabine - answer-Radiosensitizer DO NOT GIVE W/ RADIATION, except at
very low doses
Carmustine - answer-***Solvent is alcohol
Alcohol sensivity is an issue
Mix ONLY in 0.9% NaCl
Carboplatin - answer-Dose by CALVERT formula
Allergic reaction increased from 1-27% in pts receiving >6-7 courses
Cisplatin - answer-Renal toxicity
Kidney protection w/ fluids & sometimes AMIFOSTINE
MONITOR MAGNESIUM levels
Oxaliplatin - answer-NEUROTOXICITY
AVOID COLD (neuropathies exacerbated by cold exposure)
Dilute with D5W*
Cyclophosphamide - answer-HEMMORRAGHIC CYSTITIS
Blood in urine -> fluids (sometimes Mesna)
Temazolamide - answer-Headache (crosses into CNS)***
Interferons - answer-ACUTE: Flu-like Syndrome
CHRONIC: Depression- BLACK BOX WARNING
Interleukin-2 - answer-Flu-like Syndrome
Capillary Leak Syndrome
Cabazitaxel - answer-No PVC bags or tubing!
Docetaxel - answer-No PVC bags or tubing!
Paclitaxel - answer-Glass or Polyolefin container. NO PVC container or tubing.
0.22 in-line filter
with correct answers
Doxorubicin - answer-Cardiotoxic
TISSUE VESICANT
Baseline MUGA and total dose (CONCERN at 550 mg/m2)
URINE=RED
IF EXTRAVASATION OCCURS= cool/ice + Totect
Idamycin - answer-Cardiotoxic (cardiomyopathy)
Bleomycin - answer-AVOID oxygen supplementation
Methotrexate - answer-*Leukovorin decreases cytotoxicity*
Pemetrexed - answer-Vitamin B12 & folic acid supplements to decrease toxicity
Fludarabine - answer-Immunosuppression
Thioguanine - answer-Bone Marrow Suppression
Stomatitis/Mucositis
5-FU - answer-*Stomatitis
Bone marrow depression
*Diarrhea
Mucositis
Capeticibine - answer-***Pro-drug that converts 5FU in liver
Stomatitis & mucositis
Palmar-plantar erythrodysthesias (hand foot syndrome)
Cytarabine or Cytosine Arabinoside - answer-Cerebellar neurotoxicity
, Gemcitabine - answer-Radiosensitizer DO NOT GIVE W/ RADIATION, except at
very low doses
Carmustine - answer-***Solvent is alcohol
Alcohol sensivity is an issue
Mix ONLY in 0.9% NaCl
Carboplatin - answer-Dose by CALVERT formula
Allergic reaction increased from 1-27% in pts receiving >6-7 courses
Cisplatin - answer-Renal toxicity
Kidney protection w/ fluids & sometimes AMIFOSTINE
MONITOR MAGNESIUM levels
Oxaliplatin - answer-NEUROTOXICITY
AVOID COLD (neuropathies exacerbated by cold exposure)
Dilute with D5W*
Cyclophosphamide - answer-HEMMORRAGHIC CYSTITIS
Blood in urine -> fluids (sometimes Mesna)
Temazolamide - answer-Headache (crosses into CNS)***
Interferons - answer-ACUTE: Flu-like Syndrome
CHRONIC: Depression- BLACK BOX WARNING
Interleukin-2 - answer-Flu-like Syndrome
Capillary Leak Syndrome
Cabazitaxel - answer-No PVC bags or tubing!
Docetaxel - answer-No PVC bags or tubing!
Paclitaxel - answer-Glass or Polyolefin container. NO PVC container or tubing.
0.22 in-line filter
