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Samenvatting labo pathologische anatomie
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Microscopie:Normaal cervix uitstrijkje:
Squameuze cellen:
- Oppervlakkige squameuze epitheelcellen:
- Veelhoekige intermediaire cellen met veel cytoplasma:
- Parabasale cellen met basofiel cytoplasma en fijn granulair chromatine in grote celkern:
- Basale cellen uit de onderste basale laag → komt zelden voor:
Squameuze metaplastische cellen:
→ epitheelcellen uit de transformatiezone
Glandulaire cellen:
RBC, WBC, Histiocyt en macrofagen:
NILM: (Negatief voor Intra-epitheliale Laesie of Maligniteit)
- Parakeratose = verhoornde oppervlakkige squameuze cellen met een kern
- Metaplasie = vervanging van 1 soort epitheel door een ander epitheel
3 stadia: Reservecelhyperplasie, onrijpe metaplasie en rijpe metaplasie.
, - Specifieke ontsteking: Candida (A), Trichomonas vaginalis (B), Herpes (C), Gardnerella
vaginalis (D)
- Menopauze atrofie = vooral intermediaire en parabasale cellen te zien → cellen die afsterven,
celdood, bovenste cellen verdwijnen bij menopauze
- Wijzigingen in verband met een IUD (spiraaltje)
Afwijkende epitheelcellen:
ASC-US: (Atypical Squamous Cells of Undetermined Significance)
- Plaveiselcellen vh oppervlakkig of intermediair celtype met kernafwijkingen die kunnen wijzen
op een LSIL (laaggradig squameus intraepitheliaal letsel)
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