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WGU 785 2024 UPDATE COMPREHENSIVE QUESTIONS AND VERIFIED ANSWERS GET IT RIGHT GRADE A+
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WGU 785 2024 UPDATE COMPREHENSIVE QUESTIONS AND VERIFIED ANSWERS GET IT RIGHT GRADE A+
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WGU 785 2024 UPDATE COMPREHENSIVEQUESTIONS AND VERIFIED ANSWERS GET IT RIGHT
GRADE A+
polymerase chain reaction (PCR) - (correct answer) The process of
copying DNA in the lab. Uses Template DNA, Nucleotides (dNTPS), DNA
Polymerase, and DNA primers.
3 Steps of PCR - (correct answer) 1. Denaturation: DNA is heated to
95C to separate it.
2. Annealing: reaction is cooled to 50C; primers stick to the DNA you
want to copy and add DNA polymerase.
3. Elongation: reaction heated to 70C and DNA polymerase, adding
nucleotides building a new DNA strand.
Base Excision Repair (BER) - (correct answer) How you repair a
mutation. BER is used to repair damage to a base caused by harmful
molecules. You remove the base that is damaged and replace it. *BER
removes a single nucleotide*
DNA glycolsylase - sees damaged DNA and removes it.
DNA polymerase-puts the right one back in while DNA ligase seals it.
Mismatch repair (MMR) occurs during: - (correct answer)
replication. DNA polymerase proofreads but sometimes a mismatch
pair gets through. MMR removes a large section of the nucleotides
,from the new DNA and DNA polymerase tries again. (Ex: C-T instead of
C-A)
Hemophilia Pedigree - Father has hemophilia, mother does not. What is
the outcome for their kids? - (correct answer) His daughters would
be carriers. This is x-link recessive.
Autosomal:
Dominant: - (correct answer) Autosomal: males and females equally
affected.
Dominant: non-carrier parents
Mismatch Repair corrects what kind of DNA damage? - (correct
answer) When a base is mismatched due to errors in replication. Such
as G-T instead of G-C. DNA polymerase comes by and fixes it.
What happens when DNA polymerase binds to DNA to make RNA? -
(correct answer) TRANSCRIPTION! DNA polymerase takes the
individual nucleotides and matches them to the parental sequences to
ensure a correct pair. It must bind with RNA primer to work.
What is needed for DNA replication? - (correct answer) DNA
polymerase
,Nonsense Mutation - (correct answer) Change in 1 nucleotide
produces a STOP codon Stop= nonsense because it is no more.
Silent Mutation - (correct answer) Change in 1 nucleotide but codes
for the same amino acid. Silent= the change doesn't change the name
of the protein
Missense Mutation - (correct answer) Change in 1 nucleotide leads
to a code for a different amino acid. Missense = mistake was made.
What happends during RNA splicing? - (correct answer) During RNA
splicing introns are cut out, the remaining exons are joined together.
5'ATG AGT CTC TCT 3'
Find the DNA template strand. - (correct answer) 3'TAC TCA GAG
AGA 5'
The DNA template strand is complimentary. So start with the opposite
number, then go L-R with the complimentary letter.
5'ATG AGT CTC TCT 3'
What is the corresonding mRNA sequence? - (correct answer) 5'AUG
AGU CUC UCU 3'
This sequence is the same as the coding strand except T changes to U
because it is RNA. RNA doesn't have T.
, How would a mutation from CTC to ATC affect the protein sequence?
(CTC/ATC - coding strand, AUC - mRNA strand) - (correct answer)
This will make a missense mutation because it changes the name of the
protein. (look at the chart provided.) missense = mistake
DNA replication process - (correct answer) DNA ->Transcription ->
RNA -> Translation -> Polypeptide
Describe how you would find what ionized Alanine looks like. -
(correct answer) This is an amino acid. Look for the "R" group. Alanine
is a hydrophobic amino acid that has CH3. It is a weak interaction. An
ionized acid will have a + or - charge.
Describe what causes the misfolding of protein in Alzheimer's Disease. -
(correct answer) Protein misfolding is caused by intracellular tangles
and extracellular plaques (senile plaques) caused by abnormal protein
aggregation.
TAU is fibrous material inside cells where the connections are lost. This
becomes defective and forms filaments in the neuron.
Amyloid-Beta is a large precursor protein in the cell. Excess amyloid-
beta creates senile plaques. This starts in the hippocampus and moves
up.
Describe the process of neurodegenerative protein aggregation. -
(correct answer) Alzheimer's is the most common neurodegenerative
disease. The formation of aggregated amyloid-beta fibers is another
characterisitc of Alzheimer's. However, neurodegeneration and
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