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  2.  
  3. Hogeschool Utrecht (HU)
  4.  
  5. Farmacologie (TLSCDOFAR4V18)

Summary

Samenvatting Farmacologie

 6 purchases
  • Course
  • Farmacologie (TLSCDOFAR4V18)
  • Institution
  • Hogeschool Utrecht (HU)
  • Book
  • Introduction to the Pharmaceutical Sciences

In deze uitgebreide samenvatting voor farmacologie is alle leerstof samengevat a.d.h.v. de leerdoelen met de powerpoints en het boek. Farmacologie is een onderdeel uit de cursus Dierkundig onderzoek & Farmacologie.

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Document information

  • Unknown
  • June 8, 2019
  • 22
  • 2018/2019
  • Summary

Subjects

  • farmacologie
  • medicatie
  • farmacon
  • farmaca
  • eerste orde
  • nulde orde
  • kinetiek
  • farmacokinetiek
  • farmacodynamiek
  • targets
  • pharmacofoor
  • ionkanalen
  • sar
  • mtc
  • msc
  • mac
  • ld50
  • td50
  • ed50
  • ec50
  • stofnaam
  • merknaam
  • dynamiek
  • o

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Written for

  • Hogeschool Utrecht (HU)
  • Biologie en Medisch Laboratoriumonderzoek
  • Farmacologie (TLSCDOFAR4V18)
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Content preview

Farmacologie VL422


Samenvatting Farmacologie

Inhoudsopgave
College 1: Introductie Farmacologie ............................................................................................................... 3
Basisbegrippen ............................................................................................................................................ 3
Inleiding farmacologie ................................................................................................................................. 3
Geneesmiddelen en hun targets ................................................................................................................. 5
Inleiding dosis-response curve .................................................................................................................... 6
Geneesmiddelenontwikkeling en -regulatie ............................................................................................... 7
Naamgeving............................................................................................................................................. 7
Onderzoeksfasen ..................................................................................................................................... 8
College 2: Farmacokinetiek Absorptie en Distributie .................................................................................... 10
Toediendingvormen .................................................................................................................................. 10
Absorptie ................................................................................................................................................... 10
Factoren die een rol spelen bij het passeren van een membraan: ....................................................... 10
Distributie .................................................................................................................................................. 12
Afsluiting.................................................................................................................................................... 12
College 3: Farmacokinetiek Metabolisme en Excretie .................................................................................. 13
Metabolisme ............................................................................................................................................. 13
De enterohepatische kringloop ............................................................................................................. 13
CYP450................................................................................................................................................... 13
Excretie ...................................................................................................................................................... 14
De nier ................................................................................................................................................... 14
Eliminatie ............................................................................................................................................... 14
College 4: Farmacodynamiek ........................................................................................................................ 16
Signaaltransductie ..................................................................................................................................... 16
Mechanismen van farmaca ....................................................................................................................... 16
Dosis-responscurves .................................................................................................................................. 17
College 5: Cardiovasculaire Farmacologie..................................................................................................... 18
Glad spierweefsel in vaten ........................................................................................................................ 18
Hart en bloedvaten ................................................................................................................................... 19
Farmaca ..................................................................................................................................................... 19
College 6: Toxicologie .................................................................................................................................... 21
Organen ..................................................................................................................................................... 21
Modeldier de rat ....................................................................................................................................... 21

1

,Farmacologie VL422


Ames test................................................................................................................................................... 21
De MEC en MSC curve ............................................................................................................................... 22




2

, Farmacologie VL422



College 1: Introductie Farmacologie
Basisbegrippen
Zie afbeelding hieronder
Pharmacology: study of the biochemical and physiological effects of drugs on organisms.
Pharmacodynamics: study of the cellular and molecular interactions of drugs with their targets.
Pharmaceutical toxicology: study of the harmful or toxic effects of drugs.
Pharmacokinetics: study of factors that control the concentration–time relationship of drug at various
sites in the body.
Medicinal chemistry: study of drug design to optimize pharmacokinetics and pharmacodynamics, and
synthesis of new drugs.
Pharmaceutics: study and design of drug formulation for optimum delivery, stability, pharmacokinetics,
and patient acceptance.
Pharmacogenomics: study of the influence of genetic variation on drug response in patients.

An ideal drug is one that:
• Has a desirable pharmacological action
• Has no side effects
• Reaches its intended location in the right concentration at the right time
• Remains at the site of action for the necessary period of time
• Is rapidly and completely removed from the body when no longer needed.



Inleiding farmacologie
Farmacologie is een interdisciplinair vakgebied met een breed domein. Het heeft vele raakvlakken met
andere vakgebieden.
Farmacogenomics = Middels een DNA test kunnen individuele reacties op geneesmiddelen worden
bepaald. Medicijnontwikkeling wordt specifieker.




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