Exam (elaborations)
Nur 321- Intro Concepts
- Course
- Institution
Nur 321- Intro Concepts
[Show more]
Seller
Follow
modockochieng06
Content preview
Nur 321- Intro Concepts- kidney disease (more meds stay in the body)
- liver disease (continue to cause liver failure)
- acid base imbalance
- electrolyte status - ANS-What are some important determinants of drug response?
· Physiological variables: talks about the actual person
· Pathological variables: what is going on in their body
· Genetic variables- can alter the metabolism of drugs and predispose the patient to
unique interactions
Drug interactions - ANS-What affects how the drug will work in the body?
Absorption - ANS-Depends on route.
- Orally: GI tract
- Topical: skin or mucous membrane
- IV: directly into blood stream
fast and slow absorbers
additive effect - ANS-2 drugs have more of an effect combined than they would if each
were given on their own. Ex: acetaminophen and ibuprofen.
- Ibuprofen and dlaudid
- Tylenol and morphine
adverse drug interactions - ANS-undesirable drug effect that ranges from mild effect (ex:
rash, nausea) to severe toxic effects, including hypersensitivity reactions and
anaphylaxis this is like a bully- you want to get it away
allergic reaction - ANS-patient sensitivity to a medication because of an immune
response
anaphylactic reaction - ANS-a life threatening response characterized by
bronchospasm, laryngeal edema, and drop in BP. (immune response)
Antagonistic - ANS-A client presents to the ed with an overdose on heroine. Naloxone is
administered and the client starts breathing and wakes up. Which type of effect is this?
antagonistic effect - ANS-2 drugs combined decrease the effects of each other. Ex:
morphine and naloxone (reversal for opioid overdose)
, - warfarin and potassium
Bioavailability - ANS-the percentage of the administered drug that reaches the systemic
circulation
carcinogenic effect - ANS-the ability of certain meds and environmental chemicals to
cause cancer.
Distribution - ANS-how drugs are carried to site of action
- protein binding: bound to protein are inactive, and unbound drug is free and active
(determines the amount of drug and how effective it is)
drug incompatibility - ANS-chemical or physical reaction that occurs among two or more
drugs outside of the client. Example: mixing meds in IV fluid. That's why its important to
push saline before IV fluids
Drug interactions - ANS-- laboratory interactions: meds will become toxic when not in
range (digoxin & hypokalemia)
- drug induced photosensitivity
Drug interactions - ANS-altered or modified action or effect of a drug as a result of
interaction with one or multiple drugs
Effectiveness - ANS-drug that elicits the response for which its given
Elderly & chronic illness - ANS-Patients are at an increase risk of adverse drug
reactions?
Excretion - ANS-Kidneys primarily sources- decreased renal function dosage
adjustment - - half life: the period of time required for the concentration or amount of
drug in the body to be reduced by one-half (duration of action)
Fast absorbers - ANS-What are drugs that are lipid soluble and non-ionized?
first pass effect - ANS-A drug is absorbed from the GI tract and passes via the portal
vein into the liver where some drugs are metabolized. Sometimes the result of first pass
metabolism means that only a proportion of the drug reaches the circulation. Morphine
high first pass
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller modockochieng06. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
75632 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now