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Kuby Immunology Chapter 1-4.
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Kuby Immunology Chapter 1-4.
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Kuby Immunology Chapter 1-416. Which of the following statements BEST differentiates innate and adaptive immune
responses?
A. Innate responses are stronger during the primary and less important during the
secondary
response, while adaptive responses are less robust during primary responses and
stronger
during secondary responses.
B. Innate responses are weaker during the primary and more robust during the
secondary
response, while adaptive responses are stronger during the primary and weaker during
secondary responses.
C. Innate responses are slower and weaker than adaptive responses.
D. Adaptive responses are slower and weaker than innate responses.
E. Adaptive responses are required for effective immune responses, while innate
responses
are not required. - ANS-A
A large glycoprotein has been enzymatically digested in the laboratory to yield a mixture
of glycopeptides ranging in size from 4 to 6 amino acids in length. Which of the following
would be expected if the peptide mixture were administered to an exerimental animal
together with an adjuvant such as complete Freund's adjuvant?
A) peptide-specific antibodies would be generated using the peptide mixture alone
B) carbohydrate-specific antibodies would be generated only if an adjuvant were
administered with the peptide mixture
C) peptide-specific antibodies would be generated only if they were injected with a
separate uncoupled protein carrier
D) peptide-specific and carbohydrate-specific antibody and T-cell responses would be
generated using the peptide mixture alone
E) there would be neither a humoral nor cell-mediated immune response to the peptides
in the mixture - ANS-E
A polyclonal antibody made against a large protein antigen reacts with it even when it is
denatured by disrupting all disulfide bonds. Another monoclonal antibody against the
antigen fails to react when it is similarly denatured. The most likely explanation can be
stated as follows:
, A) the polyclonal antibody contains antibodies specific for several non-conformational
epitopes expressed by the antigen
B) The monoclonal antibody recognizes both conformational and non-conformational
epitopes
C) The monoclonal antibody is specific for disulfide bonds
D) The polyclonal antibody has a higher affinity for the antigen - ANS-A
A polyclonal antiserum raised against pooled human IgA will react with
A) human IgM
B) kappa light chains
C) human IgG
D) J chain
E) all of the above - ANS-E
A polyclonal antiserum raised against pooled human IgA will react with
A) human IgM.
B) k light chains.
C) human IgG.
D) J chain.
E) All are correct. - ANS-E
An adjuvant is a substance that
A) increase the size of the immunogen
B) enhances the immunogenicity of haptens
C) increases the chemical complexity of the immunogen
D) enhances the immune response to the immunogen
E) enhances immunological cross-reactivity - ANS-D
An antibody made against the antigen tetanus toxoid (TT) reacts with it even when the
TT is denatured by disrupting all disulfide bonds. Another antibody against TT fails to
react when the TT is similarly denatured. The most likely explanation can be stated as
follows:
A) The first antibody is specific for several epitopes expressed by TT.
B) The first antibody is specific for the primary amino acid sequence of TT, whereas the
second is specific for conformational determinants.
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