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MEDICAL BIOLOGY AND GENETICS for PHARMACOLOGISTS Week11 DNA Replication
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MEDICAL BIOLOGY AND GENETICS for PHARMACOLOGISTS Week11 DNA Replication
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MEDICAL BIOLOGY AND GENETICSfor
PHARMACOLOGISTS
Week11
DNA Replication
Dr. Ceyhan Ceran Serdar – 2021
,Reference Books
, Links to useful animations
https://www.youtube.com/watch?v=mxAjSBhDkBQ
https://www.youtube.com/watch?v=TNKWgcFPHqw
https://www.youtube.com/watch?v=0Ha9nppnwOc&t=187s
https://www.youtube.com/watch?v=EYGrElVyHnU
https://youtu.be/mDZLiZB0iPY
https://youtu.be/X_tYrnv_o6A
https://www.youtube.com/watch?v=efstlgoynlk
https://www.youtube.com/watch?v=kp0esidDr-c
https://www.youtube.com/watch?v=vP8-5Bhd2ag&t=266s
https://www.youtube.com/watch?v=FMcYKec-Xx4&t=2s
, Learning Objectives
Students who successfully completes this course;
1. Explain the semi-conservative mode of DNA-replication.
2. Compare the mutation rates of human genome and E. coli genome per generation.
3. Explain how cells keep the mutation rate low enough to ensure accurate transmission of genetic information
among generations, despite high mutation rate of DNA replication.
4. Describe origin of replication, replication forks, replication bubbles and replicons.
5. Explain the significance of origins of replications being AT-rich
6. Explain DNA replication, describing the roles of DNA topoisomerase, DNA polymerase, DNA helicase, SSBP,
Primase, DNA ligase.
7. Explain the significance of initiating DNA replication by RNA primers and explain how our chromosomes do
not contain RNA, although RNA primers are used in the DNA replication process.
8. Explain the bidirectional mode of DNA replication, by describing Okazaki fragments and by explaining the
events taking place on each strand during DNA replication.
9. Compare endonucleases and exonucleases, explaining their functions, and explain how they function in
resolving DNA supercoils during DNA replication.
10. Explain how DNA molecules are duplicated only once during each DNA replication.
11. Explain how epigenetic marks are preserved during each DNA replication.
12. Describe telomere, telomerase and explain how they serve a eukaryotic cell.
13. Describe the interaction between telomeres and aging and discuss whether telomerase-based strategies can
safely be used to prevent aging.
14. Explain how spontaneous mutations occur during DNA replication
15. List the endogenous and exogenous factors that cause DNA damage
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