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Summary Gastrointestinal tract drugs summarised in a table $6.15
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  3. University Of Pretoria (UP)
  4.  
  5. Pharmacology (FAR382)

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Summary Gastrointestinal tract drugs summarised in a table
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  • Course
  • Pharmacology (FAR382)
  • Institution
  • University Of Pretoria (UP)
  • Book
  • Rang & Dale\'s Pharmacology

I will soon have my Masters in Genetics and I completed my honours in Clinical Pharmacology. The pharmacology was course work on it's own, so the summaries are very well written and easy to learn. If you have Pharmacology, you will know that it is a lot of work to get in your mind in a short amount...

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Document information

  • Yes
  • June 19, 2019
  • 2
  • 2014/2015
  • Summary

Subjects

  • pharmacology
  • far 381
  • far 382
  • pharmacodynamics
  • pharmacy
  • pharmacokinetics

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  • University of Pretoria (UP)
  • Pharmacology (FAR382)
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Content preview

Ionisation
IONISED
 POLAR
 Water-soluble
 Lipophobic
 Hydrophilic
 Do not cross membranes readily

 ACIDIC drugs bind to ALBUMIN
 ACIDS are ionised in BASIC media

 BASIC drugs bind to α1-GLYCOPROTEIN
 BASES are ionised in acidic media

UNIONISED
 NON-polar
 Fat soluble
 Hydrophobic
 Lipophilic
 Diffuse more readily across a membrane
 Very HIGH L-WDC
 Distributes widely through the body
 Acts in the CNS (crosses the bbb by PASSIVE DIFFUSION)

Weak ACIDS
HA  A- + H+
¿ IONISED
 pH= pKa + log10 A− HA ¿ Ratio = UNIONISED
With a dissociation constant K
a



Weak BASES
BH+  B + H+

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