I want to help you get through all the different drug classes in Pharmacology. I have found that students struggle to get through the amount of work. These summaries helped me get through my Honours Degree. I will soon graduate with my Masters of Science in Neurogenetics. You got this!
PRINCIPLE 1: BINDING
Specific targets of drug action
Drug action is explained in terms of CONVENTIONAL
CHEMICAL INTERACTIONS
Low [D] still involve large numbers of molecules
Avogadro’s number = number of molecules found in 1 mole
of a substance
1 drop of a [D] = 10-10 mol/l contains 1010 drug molecules
Drug molecules must get so CLOSE to other molecules
that they exert a CHEMICAL INFLUENCE on them
Drug distribution = at random,
interaction (with particular cellular molecule) = negligble
D/R INTERACTION:
Depends on [D] and [R]
D-R amount determines the RESPONSE MAGNITUDE
Threshold: minimum number of D-R complexes
response
↑ [D] ↑D-R ↑ EFFECT
SATURATION = NO FURTHER ↑R
LAW OF MASS ACTION APPLIES TO D-R INTERACTION
A DRUG WILL NOT WORK UNLESS IT IS BOUND!!
, TARGETS OF DRUG ACTION:
1) SIMPLE CHEMICAL NEUTRALISATION - antacid
2) ENZYME INHIBITORS – antibiotics
o Inhibitor normal reaction INHIBITED
o False substrate ABNORMAL METABOLITE produced
o Pro-drug ACTIVE drug produced
3) R OCCUPYING DRUGS – related to NTs
o Agonist direct ion channel OPENING/CLOSING
o Agonist transduction Enzyme +/-, ion channel
modulation, DNA transcription
o Antagonist NO EFFECT, endogenous mediators BLOCKED
4) MODULATORS OF CERTAIN TRANSPORT SYSTEMS –
Na+/K+-ATPase
o NORMAL TRANSPORT
o Inhibitor transport BLOCKED
o False substrate ABNORMAL COMPUNDS accumulate
5) ION CHANNEL INTERACTION – local anesthetics
o Blockers permeation BLOCKED
o Modulators ↑/↓ opening
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller chanbain. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $6.25. You're not tied to anything after your purchase.
