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Summary Glucocortico steroids explained
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  • Course
  • Pharmacology
  • Institution
  • University Of Pretoria (UP)
  • Book
  • Rang & Dale\'s Pharmacology

I want to help you get through all the different drug classes in Pharmacology. I have found that students struggle to get through the amount of work. These summaries helped me get through my Honours Degree. I will soon graduate with my Masters of Science in Neurogenetics. You got this!

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  • Unknown
  • June 19, 2019
  • 2
  • 2014/2015
  • Summary

Subjects

  • glucocorticosteroids
  • steroids
  • pharmacology

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  • Pharmacology
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DRUG METABOLISM
TWO IMPORTANT EFFECTS:
1. The drug is made more HYDROPHILIC
 HASTENS the excretion by the kidneys
 Less-lipid soluble metabolite is not readily reabsorbed in
the renal tubules


2. The metabolites are usually LESS ACTIVE than the
parent drug

THE LIVER IS NB!




2 GENERAL TYPES OF REACTION:

PHASE 1 reactions PHASE 2 reactions
 BIOTRANSFORMATION of drugs  Drugs are made more
to a MORE POLAR metabolite HYDROPHILIC
 Introducing/unmasking a  CONJUGATION with
functional group (-OH, -NH2, -SH) endogenous compounds in
 Oxidation = most common
the LIVER
 Catalyzed by MIXED FUNCTION
OXIDASES (Cytochrome P450) TYPES OF CONJUGATION
 VERY LOW substrate specificity  Glucoronide

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