I want to help you get through all the different drug classes in Pharmacology. I have found that students struggle to get through the amount of work. These summaries helped me get through my Honours Degree. I will soon graduate with my Masters of Science in Neurogenetics. You got this!
Vasoactive amines (Histamine, 5HT) Adhesion molecules
PAF Substance P
Complement system Arachadonic acid metabolites
Kinin system Prostaglandins (PGE2) (PGs)
Cytokines main inflammatory
Nitrous oxide mediator
Thromboxane A2 (TXA2)
HETE (hydroxyl-eicosatetraenoic
acid)
Leukotrienes (LTs) – mediated by
COX
1. FLUID (vascular) phase
Acute/transient
↑ vasodilation ↑ vascular bed permeability to plasma proteins
↑ fluid helps:
i. Dilute irritant
ii. ↑ [antibodies] from blood inflamed area
iii. Supply nutrients the immune cells
2. CELLULAR (exudative) phase
Subacute
Infiltration:
i. Leukocytes
ii. Phagocytic cells
Tissue macrophages & polymorphonuclear leukocytes (PMNL) migrates inflamed area
3. FIBROUS (proliferative) phase
Chronic proliferative
Formation of:
i. New connective tissue (fibrous) containing fibroblast
ii. New capillaries
Tissue degeneration &
Fibrosis
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