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Summary Therapeutic index explained
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  • Course
  • Pharmacology
  • Institution
  • University Of Pretoria (UP)
  • Book
  • Rang & Dale\'s Pharmacology

I want to help you get through all the different drug classes in Pharmacology. I have found that students struggle to get through the amount of work. These summaries helped me get through my Honours Degree. I will soon graduate with my Masters of Science in Neurogenetics. You got this!

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Document information

  • Yes
  • June 19, 2019
  • 1
  • 2014/2015
  • Summary

Subjects

  • therapeutic index
  • pharmacology
  • ti

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  • Pharmacology
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Class Drug Indications General Adverse reactions DIs
Colchicine  ↓ risk of flares (NOT joint  Diarrhea  Erythromycin
damage)  Nausea  Simvastatin
 ONLY when NSAIDS are CI  Myelosuppresion  Cyclosporin
 ↓ clearance in renal failure  Myopathy
(danger, renal impairment)  Rabdomyolysis
 Not 1st line due to severe AEs  Renal failure

Urate Allopurinol  Frequent attacks  Purine analogs
lowering  Tophaceous gout  Inhibits XO
 Gout with renal failure  Substrates of XO
 Recurrent stones  Thus blocking
 High serum urate levels hypoxanthinexanthineuric
(males 0.77Um/l, females acid
0.59Um/l)
 Urinary urate = >
6.5mmol/day

Newer Febuxostat  Treatment of chronic  Selective XO inhibitor  Liver toxicity?
therapies hyperuricaemia (conditions  Minimal excretion in the urine
where urate deposits has  Can administer in renal
already occurred) insufficiency and mild/moderate
 Management of chronic hepatic insufficiency with no
hyperuricaemia in gout in dosage adjustments
allopurinol is not tolerated or
CI

Uricosuric  Probenecid Mild uricosuric agents:
agents  Benzbromar  Losartan (Cozaar)
one (ex-US)  Fenofibrate
 Sulfinpyrazo
ne (ex-US)

Recombinan Rasburicase Recombinant porcine-like Pegloticase  ↓ risk of
t urate uricase Metabolizes: precipitates
oxidase Ric  Treat resistant gout
acidallantoin(m
ore soluble)

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