Section 1: Cellular Physiology 1 Principles of Cell and Membrane Function 2 Homeostasis: Volume and Composition of Body Fluid Compartments 3 Signal Transduction, Membrane Receptors, Second Messengers, and Regulation of Gene Expression Section 2: Neurophysiology 4 The Nervous System: Introduction to...
Berne and Levy Physiology 7th Edition KoeppenTest Bank
Koeppen: Berne and Levy Physiology, 7th Edition
Chapter 01: Principles of Cell
FunctionTest Bank
Multiple Choice
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1. The subcellular structure that degrades proteins is called the:
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A. Tight junction
B. Mitochondria
C. Lysosome
D. Plasma membrane
E. Ribosome
C
ANS: C
2. An experiment is done to measure the uptake of an amino acid into a cell. The following
O
data are obtained:
N
N
N
O
If Na+ is removed from the extracellular bathing solution, or if a drug is added that prevents the
cell from making adenosine triphosphate (ATP), the uptake of amino acid into the cell is
markedly reduced. According to this information, which of the followingmechanisms is
IS
probably responsible for the transport of the amino acid into the cell?
A. Passive diffusion through the lipid bilayer
SE
B. Uniporter
C. Transport ATPase
D. Na+ symporter
E. Na+ antiporter
ANS: D
U
3. A membrane permeable by only Na+ separates two compartments containing
Na2SO4,shown as follows:
R
, Electrodes are placed in both compartments, and a voltage is applied (that of compartment A is
M
held at 0 mV). What voltage applied to compartment B would result in no net movement of Na+
across the membrane separating the compartments?
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A. –60 mV
B. –30 mV
C. 0 mV
D. +30 mV
E. +60 mV
C
ANS: E
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4. The resting membrane potentN cellGis –B
ial oRf a I 85.C
mV. The intracellular and extracellular
U S N T
concentrations of several ions are indicated in the following table, as is the calculated
Nernst equilibrium potential (Ei) for each of these ions:
N
Ion Concentration Concentration Ei
Inside Cell Outside Cell
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The cell is treated with a drug to inhibit the Na+,K+-ATPase. What would be the effect ofthis drug
on the following parameters?
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Intracellular [Na+] Intracellular [K+] Cell Volume Membrane Voltage
A. Decrease Decrease Decrease Depolarize
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B. Increase Decrease Increase Depolarize
C. Increase Increase Increase No change
D. Decrease Increase Decrease Hyperpolarize
E. Increase Increase Decrease Hyperpolarize
C
ANS: B
6. Which of the labeled proteins (shaded) is attached to the membrane by a
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glycosylphosphatidylinositol (GPI) anchor?
N
N
O
ANS: E
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7. A cell has channels for Na+, K+, and Cl– in its plasma membrane. The resting membrane
potential is –60 mV (cell interior negative). The intracellular and extracellular
SE
concentrations for these ions, as well as the calculated Nernst potentials, are listed as
follows:
U
R
, Ion Intracellular Extracellular Ei
Concentration Concentration
Na+ 14 mEq/L 140 mEq/L 60 mV
K+ 150 mEq/L 5 mEq/L –89 mV
M
Cl– 10 mEq/L 100 mEq/L –60 mV
A drug is applied to the cell that increases the permeability of the cell by Cl– (i.e., it opens Cl–
ED
channels). What effect will this drug have on the net movement of Cl– acrossthe plasma
membrane?
A. Net Cl– movement out of the cell will be increased.
B. Net Cl– movement into the cell will be increased.
C
C. There will be no change in the net movement of Cl–.
ANS: C
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Reducing the extracellular [K+] would be expected to have which of the following
N
8.
effects on the resting membrane potential and on the excitability of ventricular
myocytes?
N
Membrane Potential Excitability
A. Unchanged Unchanged
O
B. Hyperpolarized GDT
ecBre.aC
seO
d
C. Hyperpolarized Increased
IS
D. Depolarized Decreased
E. Depolarized Increased
SE
ANS: B
9. A cell is bathed in an isotonic NaCl solution that contains 5 mmol/L of glucose. The
intracellular concentration of glucose is 10 mmol/L. What is the most likely mechanism
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for the transport of glucose across the plasma membrane into this cell?
A. Glucose uniporter
R
B. Na+-glucose symporter
C. Na+-glucose antiporter
D. Diffusion of glucose through the lipid bilayer of the membrane
ANS: B
10. A blood sample is taken from an individual whose blood osmolality is 295 mOsm per
kilogram of water. Red blood cells from this sample are then placed in the following
solutions:
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