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Class notes Farmacología
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Taller análisis de formulación_HTA_
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UNIVERSIDAD DE MANIZALES – ESCUELA DE MEDICINA. FARMACOLOGÍA – 2023TALLER FARMACOLOGÍA APLICADA CARDIOVASCULAR
Considere los siguientes pacientes adultos valorados en el servicio de consulta externa, donde se generaron las siguientes formulaciones y se midió la PA:
P Edad Sexo Peso Talla FC Creatinina K+ HTA + Patología adicional Medicamento1 Dosis1 Medicamento2 Dosis2 Medicamento3 Dosis3 PA
1 40 H 67 166 53 1.2 3.0 Bradicardia Hipercolesterolemia Furosemida 240 Carvedilol 6,5 Verapamilo 160 200/99
2 45 M 84 179 80 1.5 3.5 Diabetes T2 Hiperuricemia Enalapril 40 Hidroclorotiazida 25 Losartan 200 152/90
3 56 M 69 166 76 1.4 3.1 Gastritis Cálculos renales Nifedipino 160 Amlodipino 10 Furosemida 80 146/90
4 62 H 82 170 58 1.8 5.6 ICC Hiperplasia prost. Benig Hidroclorotiazida 50 Nifedipino 60 Verapamilo 160 148/84
5 55 M 69 167 101 1.2 3.8 Taquicardia Hiperuricemia Amlodipino 10 Furosemida 40 Losartan 100 130/80
6 59 M 73 178 86 2.0 5.7 ERC Hipocalcemia Verapamilo 160 Metoprolol 100 Losartan 150 160/98
7 63 H 73 165 86 1.2 3.4 ICC Hipercolesterolemia Losartan 150 Amlodipino 10 Hidroclorotiazida 25 150/90
8 68 H 80 170 104 1.6 3.0 EPOC Hipercolesterolemia Hidroclorotiazida 25 Clonidina 150 Propranolol 160 90/60
9 51 M 77 168 116 1.4 3.0 Taquicardia ERC Amlodipino 15 Clortalidona 5 Losartan 100 144/88
10 71 M 102 160 50 1.2 3.4 Obesidad Hiperglicemia Enalapril 60 Furosemida 80 Valsartan 100 150/91
Complete el siguiente cuadro en función del proceso de análisis de las formulaciones asociadas a las condiciones de los pacientes:
Análisis general de la Análisis general de la Posible RAM (principal) de la Si COMBINACIÓN = Inadecuada, Dosis del medicamento
P
combinación Dosis combinación de medicamentos ¿Cuál es la sugerida? modificado
Furosemida adecuada
en mg/día
Inadecuada
1 Carvedilol inadecuado Bradicardia Verapamilo con furosemida
Verapamilo adecuado
en mg/día
Enalapril inadecuado Losartan 50mg/día via
Enalapril y Losartan
Hidroclorotiazida Hipotension, deterioro renal, oral
2 inadecuado Losartan e hidroclorotiazida
inadecuado hiperpotasemia Hidroclorotiazida
Losartan inadecuado 50mg/dia via oral
Nifedipina inadecuada
Nifedipina y amlodipino
Amlodipino adecuada Bloqueos, falla cardiaca , aumenta la Amlodipino 10mg/dia
3 Inadecuado Amlodipino y furosemida
Furosemida acidez estomacal Furosemida 100mg/dia
inadecuada
Nifedipina y verapamilo Verapamilo 150 mg/dia
4 Inadecuado Inadecuado Bloqueos AV, ICC con eyeccion reducida Verapamilo e hidroclorotiazida Hidroclorotiazida
50mg/dia
Adecuado
5
Inadecuada verapamilo y Edema de miembros inferiores
Verapamilo 100mg/dia
6 metropolol Inadecuado Se debe hacer vigilancia de la función Verapamilo con Losartan
Losartan 40mg/dia
renal
Inadecuada por clonidina
7 Hipotension Hidroclorotiazida y clonidina
y propanolol
8
9 Adecuada
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