Exam (elaborations)
ILE VI- HTN 2.
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Exam of 13 pages for the course testiilvcn at testiilvcn (ILE VI- HTN 2.)
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ILE VI- HTN 2Comorbid conditions where specific antihypertensive drug classes have
been shown in clinical trials to reduce CV events
Compelling indications
HFrEF
First line
ACEi or ARB then add beta blocker, diuretic if edema present
which beta blockers are used in HFrEF
Use bisoprolol, carvdeidolol, or metoprolol succinate
HFrEF add on
Mineralcorticoid receptor antagonist (spironolactone)
HFpEF
First line
ACEi or ARB then add beta blocker, diuretic if edema present
Stable ischemic heart disease
First line
Beta blocker then add ACEi or ARB
Stable ischemic heart disease add on
CCB if angina
Then
Thiazide or mineralcorticoid receptor antagonist
Diabetes mellitus
, First line
ACEI, ARB, CCB, or thiazide
if albuminuria present in diabetes mellitus treat like
CKD
CKD
First line
ACEi or ARB
Secodnary stroke prevention
First line
Thiazide or thiazide with ACEi
Beta Blockers Block beta receptor preventing the
Gs receptor from converting ATP to cAMP decreasing calcium release
and contraction
beta blockers three fold effect
Decrease HR
Decrease renin release
Decrease sympathetic outflow
beta blockers structure
Take NE and remove catechol functionality
if beta blocker are para substituted
beta 1 selectivity
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