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Summary on Hypothyroidism Chapter from Harrison's Principles of Internal Medicine, 21st. ed. $10.49   Add to cart

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Summary on Hypothyroidism Chapter from Harrison's Principles of Internal Medicine, 21st. ed.

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This document provides a comprehensive summary of Chapter 383 from the 21st edition of Harrison's Principles of Internal Medicine, which focuses on hypothyroidism. The summary distills key points and essential information, including: Definition and Etiology: Explanation of hypothyroidism, its pr...

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  • Chapter 383
  • June 9, 2024
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  • 2023/2024
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HYPOTHYROIDISM
Harrison's Principles of Internal Medicine, 21st ed., Ch 383
Causes, Clinical Manifestations, and Laboratory Evaluation


Causes ● MCC: Iodine deficiency




Congenital Hypothyroidism

Prevalence ● Transient: if mother has TSH receptor-blocking antibodies or has received
antithyroid drugs
● Permanent: majority
● Causes:
○ Thyroid gland dysgenesis
○ Inborn errors of thyroid hormone synthesis
○ TSH-R antibody mediated
● F>M

, ● Transplacental passage of maternal thyroid hormone occurs before fetal thyroid
gland begins to function → provides partial hormone support to fetus with
congenital hypothy




Clinical ● Use of biochemical screening
Manifestations ● Features:
○ Prolonged jaundice
○ Feeding problems
○ Hypotonia
○ Enlarged tongue
○ Delayed bone maturation
○ Umbilical hernia
○ + typical adult manifestations of hypothy
○ + cardiac congenital malformations
● Permanent neurological damage if tx is delayed1

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