Essay
FABA204 Biological Medicines Elevate Group Project Avonex
- Course
- Institution
Elevate group project on the drug Avonex.
[Show more]
1 review
By: mstanicevic • 4 year ago
Seller
Follow
UUValerie
Reviews received
Content preview
JANUARY 20, 2019AVONEX: INTERFERON BETA-1A
FA-BA204: BIOLOGICAL DRUGS
Valerie van den Heuvel: 6520472
Bilge Kaymakci: 6126154
Jochem Wolfert: 5753295
, Abstract
In the last decade, recombinant proteins have become commercially important predominantly because
of their high specificity for molecular targets. Because these generally called biologicals are in many
aspects different from small molecules, many challenges in the development of cost effective and
efficient production of recombinant proteins on commercial scale are found. This assay will focus on
Avonex, an analog to interferon beta-1a (IFN-β1a) and currently used for treatment of multiple sclerosis
(MS). It exerts its therapeutic effects by down-modulating the systemic immune response and cytokine
signaling by targeting its two receptors IFNAR1 and IFNAR2c, both cell surface receptors which
activate the JAK-STAT signaling pathway. This assay will elaborate on several aspects regarding the
indications where Avonex is used for, molecular targets, production (upstream and downstream
processing), formulation and stability issues, and clinical observed side effects.
Page 1/9
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller UUValerie. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $4.27. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
53068 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now