Lecture notes BI505 Infection And Immunity (BIOS5050) on Immunopathology
8 views 0 purchase
Course
BI505 Infection And Immunity (BIOS5050)
Institution
The University Of Kent (UKC)
Unlock your academic potential with my notes on Immunity and Infection, tailored specifically for students pursuing Biomedical Science, Biochemistry, Immunology Biology, Biomedical Engineering and Nursing. These notes are perfect for anyone looking to excel in their studies and gain a deep understa...
Dr elizbeth curling, dr gary robinson, alex moores
All classes
Subjects
immunopathology
infection
immunity
immunity and infection
bioscience
university of kent
Written for
The University of Kent (UKC)
Unknown
BI505 Infection And Immunity (BIOS5050)
All documents for this subject (22)
Seller
Follow
morgan_helene
Content preview
Lecture: Infection and Immunity
Date: Thursday 22nd February
Time: 11am – 12pm
Immunopathology
This is where immunology causes us disease, due to the genotype, infection etc. We are
going to discuss several things, including:
- Hypersensitivity (type1 = allergy to pollen) – it can be serious or mild.
- Auto (self) immunity – building t cells against our own tissue, causing disease.
- 4 types of sensitivity
- Immunodeficiency disease – body can’t make t cells and need a bone marrow
transplant.
- Transplant rejection – matching donor and recipient but unless we have an identical
twin, we cannot have a 100% match.
Triggers for autoimmunity
Figure 1: Genetic factors depend on what our parents have given us, exposure to the
environment. In some cases, we may have an immune dysregulation. We produce t
regulatory cells that may not work in that individual.
Figure 2: Venn diagram of 4 important factors: Environmental, Genetic, and immune
regulation, which influence autoimmune disease.
Four main causes of autoimmune reactions:
1) Release of normally hidden antigens.
2) Molecular mimicry between foreign and self-antigens.
3) Inappropriate MHC class 2 expression on non-antigen presenting cells (due to high
levels of IFN – gamma present in the tissue.
4) Super antigens that cause a cytokine storm, which activate polyclonal T cells and V
cells.
5) Gender: 78% of autoimmune diseases in the US are in women.
Pathways used in the induction of autoimmunity.
Yellow: represents reasons for setting off an autoimmune response (release of antigens,
molecular mimicry, or inappropriate expression of MHC class 2).
(image on slide)
Sequestered self-antigens.
Example 1: Trauma to your eye socket causes interocular antigens to be released into the
blood stream. The antigens enter local lymph node and activates T cells. T cells migrate out
1
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller morgan_helene. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $13.54. You're not tied to anything after your purchase.
