Lecture notes BI505 Infection And Immunity (BIOS5050) on Antigen Processing and Presentation
6 views 0 purchase
Course
BI505 Infection And Immunity (BIOS5050)
Institution
The University Of Kent (UKC)
Unlock your academic potential with my notes on Immunity and Infection, tailored specifically for students pursuing Biomedical Science, Biochemistry, Immunology, Biology, Biomedical Engineering and Nursing. These notes are perfect for anyone looking to excel in their studies and gain a deep underst...
Dr elizbeth curling, dr gary robinson, alex moores
All classes
Subjects
antigen processing
antigen presentation
antigen
immunology
infection
immunity
immunity and infection
university of kent
bioscience
bios5050
antigen processing and presentation infection
Written for
The University of Kent (UKC)
Unknown
BI505 Infection And Immunity (BIOS5050)
All documents for this subject (22)
Seller
Follow
morgan_helene
Content preview
Lecture: Infection and Immunity
Date: Thursday 15th February
Time: 11am – 12pm
Antigen Processing and Presentation
Last week we discussed B cells, antibodies, how we produced them and how we secrete
different classes of antibodies. Today we are going to discuss T cells, which need to see MHC
molecules that hold a small peptide of collagen and only then can the t cell become
activated. Only a few types can present to T helper cells to become activated. Whereas
cytotoxic t cells, can produce antigens in any cell in our body. This makes sense as any cell in
our body can become infected, so this process needs to be possible in all cells with a
nucleus.
Learning objectives:
- Histocompatibility gene complex (Histo = skin)
- The cytosolic pathway of antigen processing
- What are immunoevasions? Most pathogenic viruses have methods to get around
the immune system which prevent the cytosolic pathway processing.
- The endocytic pathway: only antigen presenting cells use this pathway, activating
helper t cells.
- Toll like receptors (TLRs): on the surface of a membrane, on an antigen presenting
cell. These recognise the pathogen and switch on the correct immune response.
- B cells processing and presenting antigen
MHC Variability
Case study: Cheetahs MHC variability went down to nothing. From a few pairs we were able
to build up the cheetah population. Now cheetahs have almost identical MHC factors, luckily
the human population has a varied range of MHC. Stopping the population from dying from
a virus.
Human Leukocyte Antigen (HLA):
Class 1: A,B and C
Class 2: DP, DQ, DR
Diversity: 6 different types of class 1 HLA molecules and 12 different types of class 2 HLA
molecules. We have huge numbers of Alleles in the human population.
We get our haplotype from our mother and father; these are both dominant and can
present antigens to our immune system. Four children from the same parents will have
slightly different MHC molecules. This makes it difficult to donate skin grafts to others. There
is something on the surface of skin cells that can’t produce compatibility, MHC molecules.
MHC 2 is found on antigen presenting cells.
Mate selection of MHC
1
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller morgan_helene. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $13.54. You're not tied to anything after your purchase.