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BICH 411 New Information for the Final TAMU - Miles.
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BICH 411 New Information for the Final TAMU - Miles.
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BICH 411 New Information for the FinalTAMU - Miles
Adenosine - ANS-
Guanosine - ANS-
Inosine - ANS-
Xanthosine - ANS-
Hypoxanthine - ANS-
Xanthine - ANS-
Uracil - ANS-
Uridine - ANS-
Cytidine - ANS-
Cytosine - ANS-
Thymidine - ANS-
Caffeine - ANS-
Urate - ANS-
5-phosphoribosylpyrophosphate (PRPP) - ANS-
Carbamoyl Phosphate Synthesis II - ANS--Takes glutamine, bicarbonate, and 2 ATP to
make Carbamoyl Phosphate, 2 ADP, glutamate, and Pi
-Three active sites:
1) Glutamine hydrolysis
2) bicarbonate phosphorylation
3) carbamate phosphorylation
-Active sites connected by a channel
, CPSI vs CPSII - ANS--both make carbamoyl-phosphate
-CPSI uses free ammonia and is used in the urea cycle
-CPSII uses glutamine and is used in purine biosynthesis
Aspartate Transcarbamoylase - ANS-Links carbamoyl phosphate and aspartate by
shedding the Pi and linking the NH3 group in its place to make carbamoyl aspartate
Dihydroorotase - ANS-Brings in H+ and Links the NH2 group of what was the carbamoyl
phosphate to what was the COO of what was aspartate to make a hexane ring,
dihydroorotate
Dihydroorotate dehydrogenase - ANS-reduces dihydroorotate into orotate using NAD+
Pyrimidine phosphoribosyltransferase - ANS-Links orotate and PRPP, releasing PPi to
form orotidylate (OMP)
Orotidylate Decarboxylase - ANS-Hydrolyzes off CO2- to make UMP
Nucleotide Monophosphate Kinase - ANS-Uses ATP to phosphorylate UMP into UDP
Nucleotide diphosphate kinase - ANS--Uses ATP to phosphorylate UDP into UTP
-final step of pyrimidine biosynthesis for Uracil
CTP Synthetase - ANS--Phosphorylates the top ketone of UTP using ATP, and then
uses Glutamine to swap the phosphate for an amine, making CTP
-also has a glutamine amidotransferase domain
-Final step for Cytosine biosynthesis
Uracil atom origins - ANS--the bottom carbonyl and the adjacent N not attached to
ribose came from Carbamoyl phosphate (the N coming from glutamine
-the rest of the ring came from aspartate
Cytosine atom origins - ANS--the bottom carbonyl and the adjacent N not attached to
ribose came from Carbamoyl phosphate (the N coming from glutamine)
-the rest of the ring came from aspartate
-the top NH2 came from glutamine
Glutamine phosphoribosyl amidotransferase - ANS--first step of purine biosynthesis
-glutamine amidotransferase domain
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