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BICH 411-Final
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Exam of 12 pages for the course BICH 411 Exam 1 at BICH 411 Exam 1 (BICH 411-Final)
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BICH 411-FinalCatalyzes an oxidation-reduction reaction forming NADH and 1,3-bisphosphoglycerate -
ANS-Glyceraldehyde-3-Phosphate DH
Requires a phosphohistidyl residue for catalytic activity - ANS-Phosphoglycerate
mutase
Utilizes covalent catalysis where cysteinyl serves as a nucleophile -
ANS-Glyceraldehyde-3-PhosphateDH
An enzyme found specifically in red blood cells - ANS-Bisphosphoglycerate mutase
An enzyme that functions in glycolysis by catalyzing a dehydration reaction -
ANS-Enolase
Priming reactions in glycolysis refer to those that have which of the following
characteristics? - ANS-Those that require investment in the form of ATP serving as a
phosphate donor
Which of the following statements is FALSE concerning the reaction mechanism shown
above? - ANS-E-S complex facilitates covalent catalysis
The reaction shown above is catalyzed by which of the following enzymes? -
ANS-Triosephosphate isomerase
Consider that the 6C-containing glucose molecule is cleaved into two 3C-containing
molecules, each containing a critical phosphate modification. Which of the following
does NOT describe an important occurrence to allow for this in the glycolytic pathway? -
ANS-Covalent catalysis must occur in order for aldolytic cleavage to be possible
Consider the following enzyme classifications. Which pairs serve to the action of the
other based on your understanding in carbohydrate metabolism? -
ANS-Kinases/Phophatases
Which of the following is an effect of fructose-2,6-bisphosphate? - ANS-It allosterically
activates PFK-1 in the liver
, Which of the following is NOT a purpose served by the pentose phosphate pathway? -
ANS-Generate NADH for the purpose of generating electrons for rapid rates of oxidative
phosphorylation.
Which enzyme utilizes GTP to facilitate formation of phosphoenolpyruvate? -
ANS-Phosphoenolpyruvate carboxykinase
Which TCA cycle intermediate activates fructose-1,6-bisphophatase and inhibits
PFK-1? - ANS-Citrate
What is the enzyme that catalyzes the production of the molecules shown above? -
ANS-PFK-2
Hydrolysis of this molecule produces all but which of the following? - ANS-An inhibitor
for PFK-1
Under conditions of aerobic exercise, what is the fate of pyruvate in muscle? -
ANS-Conversion to acetyl-CoA
If 100 glucose molecules are consumed aerobically vs anaerobically is a human, what is
the difference in the amount of ATP generated based on the approximate yield
discussed in class? - ANS-3600 ATP
Which of the following enzymes is part of glycolytic, gluconeogenic and pentose
phosphate pathways? - ANS-Glyceraldehyde-3-Phosphate DH
Which of the following is not a role for fructose 6-phosphate? - ANS-Product of fructose
kinase
The mechanism in which a base abstracts a proton to facilitate a enediol intermediate is
used in all but which of the following enzymes? - ANS-Enolase
Covalent catalysis is used by all but which of the following enzymes? - ANS-Class II
aldolase
Pyruvate is deprotonated for nucleophilic attack in mechanism of which of the following
enzymes? - ANS-Pyruvate carboxylase
Which of the following cannot serve as the carbon source for glucose biosynthesis? -
ANS-Fatty acids
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