Notes and BNF summaries to revise for the GPhC foundation year exam, particularly paper 2. All notes are focused on each disease state rather than the chapter, as nowadays the chapter weightings are beginning to make less of an impact on how the exam is structured.
- DECREASE the CONCENTRATION and EFFECTIVENESS of other drugs
- Full effect seen after several weeks
SULFONYLUREAS
CARBAMAZEPINE
RIFAMPICIN
ALCOHOL (BINGE-DRINKING)
PHENYTOIN
GRISEOFULVIN
PHENOBARBITAL
ST JOHNS WORT
SMOKING
Enzyme INhibitors
- INCREASE the CONCENTRATION and TOXICITY of other drugs
SODIUM VALPROATE
ISONIAZID
CIMETIDINE
KETOCONAZOLE
FLUCONAZOLE
CHLORAMPHENICOL
ERYTHROMYCIN
SULFONAMIDES
OMEPRAZOLE
METRONIDAZOLE
GRAPEFRUIT JUICE
CIPROFLOXACIN
Clinical trial pyramid (highest to lowest quality of evidence)
1) Meta analyses
2) Systematic reviews
3) Critically appraised literature + EPM guidelines
4) RCTs
5) Non- RCTs
6) Cohort studies
7) Case studies or series
8) Individual case reports
9) Background information + non- EPM guidelines
FMD
- Type of initiative of FMD EU driven initiative
- Purpose of FMD prevents fake medicines from being in circulation therefore protecting
safety of patients
- Elements of packaging
- Anti-tampering device (ATN)
- Unique identifier (2D barcode)
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