These revision notes delve into the developmental programs that control brain wiring to understand the cues that trigger neurons to take the correct shape and connect with appropriate partners. My revision notes also concisely explore how understanding neural circuit assembly suggests ways of treat...
The specification of the nervous system
In Drosophila the nervous system develops in the ventral side
The nervous system is derived from the progenitors of skin
Neuroblasts are the equivalent of neural stem cells
Different genes are activated in different regions of the nervous system
Allows cell differentiation within the nervous system
Transcriptional factors involved
Neuroblasts can become many types of cells within the nervous system
E.g. neurons and glial cells
Specific molecular markers revealing the unique identity and specification of NB
lineages can label each neuroblast lineage in the Drosophila embryo
Each neuroblast lineage produces a stereotypic progeny of neurons and/or glial
cells
Neuroblasts divide asymmetrically
NB = Neuroblast
GMC = ganglion mother
cell
G = Glial cell
N = Neuron
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