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Pharm - Antiarrhythmics Questions with 100% Actual correct answers | verified | latest update | Graded A+ | Already Passed | Complete Solution

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Pharm - Antiarrhythmics Questions with 100% Actual correct answers | verified | latest update | Graded A+ | Already Passed | Complete Solution

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  • June 19, 2024
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  • 2023/2024
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Pharm - Antiarrhythmics
how are the class 1 drugs broken down? what are their "speeds"?
1A - intermediate
1B - fast
1C - slow


what are class 1 drugs?
Sodium channel blockers


what are class 2 drugs?
beta blockers


what are class 3 drugs?
Potassium channel blockers


what are class 4 drugs?
calcium channel blockers


What are the class IA anti-arrhythmics?
Quinidine
Procainamide
Disopyramide


Which Class IA antiarrhythmic can cause a reversible lupus-like
syndrome?
Procainamide


Which Class IA antiarrhythmic has anticholinergic effects?
Disopyramide

,(dry mouth, urinary retention, blurred vision, constipation)


What is the MOA for Class IA antiarrhythmics?
-Binds to open and inactivated sodium channels and prevents sodium
influx
- Decreases phase 0
- Decreases myocardial excitability and conduction velocity and
myocardial contractility
- results in slowing conduction velocity and increased refractoriness


what are the adverse effects of quinidine
arrhythmias (TdP), SA and AV blockade, asystole, GI distress,
cinchonism at high doses (blurred vision, tinnitus, HA, disorientation,
psychosis), increase digoxin levels


what are some drug interactions of quinidine
antifungals (itraconazole, voriconazole, posaconazole)




What is different about disopyramide MOA?
Same as other 1A's except also has a negative inotropic effect and
peripheral vasoconstriction




what are adverse effects of Procainamide?
•Reversible lupus-erythematosus-like syndrome
•Toxic concentrations may cause asystole
•CNS side effects (depression, hallucinations, psychosis)
•Hypotension (IV)


do the class 1A drugs require dose adjustments?

, YES - adjust for renal impairment


how do you dose Disopyramide?
weight based!

> 50kg start w 300mg

<50 kg start with 200 mg




how much of the oral dose of disopyramide is excreted unchanged by
the kidneys?
1/2


what are the adverse effects of Disopyramide?
anticholinergic effects, hypotension, CHF


What agents are in the Class IB antiarrhythmics?
Lidocaine
Mexiletine


What is the MOA of Class IB antiarrhythmics?
Rapidly associates and disassociates from sodium channels with actions
manifested when the cardiac cell is depolarized or rapidly firing

Shortens phase 3 repolarization and decreases the duration of AP


how is lidocaine administered? why?
IV only due to extensive first pass metabolism

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