Verified | 2024 Version
If Evelyn eats a fat-free diet, where does fatty acid (FA) synthesis occur?
a. Muscle and kidney
b. Liver and adipose
c. Intestine and Pancreas
d. All of the Above - ✔✔Liver and adipose
What is the major source of carbons for fatty acid synthesis if Evelyn eats a fat-free diet?
a. Endogenous fatty acids
b. Exogenous TAG
c. Fatty Acids from adipose tissue
d. Dietary Glucose - ✔✔Dietary Glucose
What enzyme controls the synthesis of Malonyl CoA during fatty acid synthesis if Evelyn eats a fat-free
diet?
a. Acetyl CoA Carboxylase
b. Citrate lyase
c. Malic Enzyme
d. FA Synthase - ✔✔Acetyl CoA Carboxylase
What enzyme adds 2 carbon units each time from Malonyl CoA to the growing FA chain if Evelyn eats a
fat-free diet?
a. Acetyl CoA Carboxylase
,b. Citrate lyase
c. Malic Enzyme
d. FA Synthase - ✔✔FA Synthase
What are enzymes responsible for the formation of NADPH from OAA cycle for fatty acid synthesis if
Evelyn eats a fat-free diet?
a. Citrate lyase, mitochondrial malate dehydrogenase, citrate synthase
b. Citrate lyase, cytosolic malate dehydrogenase, malic enzyme
c. NADPH synthase, malic enzyme, citrate dehydrogenase
d. NADPH synthase, citrate lyase, mitochondrial malate dehydrogenase - ✔✔Citrate lyase, cytosolic
malate dehydrogenase, malic enzyme
Which of the following is correct for the Pentose Phosphate Pathway if Evelyn eats a fat-free diet?
a. Generation of NADPH necessary for amino acid, cholesterol and fatty acid synthesis
b. It is an alternative to Glycolysis when G-6-P is elevated
c. Ribose-5-P can be used for nucleotide and nucleic acid synthesis
d. All of the above - ✔✔a. Generation of NADPH necessary for amino acid, cholesterol and fatty acid
synthesis
b. It is an alternative to Glycolysis when G-6-P is elevated
c. Ribose-5-P can be used for nucleotide and nucleic acid synthesis
What are enzymes responsible for the formation of NADPH in Pentose Phosphate Pathway for FA
synthesis if Evelyn eats a fat-free diet?
a. G-6-Pase, NADPH synthase
b. Mitochondrial malate dehydrogenase, malic enzyme
, c. G-6-P Dehydrogenase, 6-Phosphoglucanate Dehydrogenase
d. Citrate lyase, mitochondrial malate dehydrogenase - ✔✔G-6-P Dehydrogenase, 6-Phosphoglucanate
Dehydrogenase
Which of the following is false regarding Acetyl CoA Carboxylase?
a. It is regulated by allosteric regulation, covalent modification, and induction of its
synthesis
b. Evelyn's fat-free diet could cause a decrease in acetyl CoA Carboxylase synthesis
c. AMPK kinases is activated by cAMP-dependent protein kinase A (PKA)
d. Acetyl CoA Carboxylase is active when it is dephosphorylated - ✔✔Evelyn's fat-free diet could cause a
decrease in acetyl CoA Carboxylase synthesis
On a fat-free diet, increased _______ is an allosteric activator of acetyl CoA carboxylase and
promotes the ______ of acetyl CoA Carboxylase in Evelyn's liver.
a. Palmitoyl CoA; Depolymerization
b. Palmitoyl CoA; Polymerization
c. Citrate; Polymerization
d. Increase Insulin/glucagon ratio, Dephosphorylation - ✔✔Citrate; Polymerization
On a fat-free diet, increased _______ is an activator of acetyl CoA carboxylase and promotes the ______
form of acetyl CoA Carboxylase in Evelyn's liver.
a. Palmitoyl CoA; Depolymerization
b. Protein phosphatase; active
c. AMPK; active
d. AMPKK, Dephosphorylation - ✔✔Protein phosphatase; active
When Evelyn decided to stay on a fat-free diet, which of the following are dietary essential fatty acids?