Summary

Intro. to nanomedicine and drug targeting - complete summary

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Course
Introduction to Nanomedicine and Drug Targeting (WBFA06005)

Institution
Rijksuniversiteit Groningen (RuG)

This summary completely covers all materials discussed in the course intro to nanomedicine and drug targeting in June 2024. 1. nanocarriers and liver targeting 2. cellular uptake of nanoparticles and kinetics 3. stimuli-responsive nanoparticles and approved medicines The course is subject to m...

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Uploaded on June 21, 2024
Number of pages 52
Written in 2023/2024
Type Summary

nanomedicine
drug targeting
stimuli responsive
drug carriers
lipid nanoparticles
magnetic hyperthermia
exogenous stimuli
tumor targeting
active targeting
pegylation
photothermal therapy

Institution
Rijksuniversiteit Groningen (RuG)
Education
Farmacie
Course
Introduction to Nanomedicine and Drug Targeting (WBFA06005)

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Introduction to Nanomedicine
and Drug Targeting
Rijksuniversiteit Groningen: WBFA060-05, June 2024

Do not plagiarize the posters

, Learning outcomes
1. Describe different strategies for drug targeting, personalized medicine and theranostics as well as innovative
experimental approaches for the development of targeted drugs (monoclonal-based therapies and protein-based
drug targeting strategies)
2. analyze the properties of the currently approved nanomedicines and major types of drug carriers and their
characteristics, as well as describe novel targeting and therapeutic strategies based on stimuli-responsive drug
carriers
3. Explain the different physiological barriers to drug delivery and (immune) cell-based clearance mechanisms, as we
as describe the cellular uptake and intracellular distribution of nanomedicines and targeted drugs and their
consequences

Content
Block 1 Introduction to drug delivery and drug targeting strategies 5

Block 2 Overview of main nanomedicine types, uptake & intracellular targeting 22

Block 3 Other targeting strategies with stimuli-responsive materials 31
*no book reading → research papers

Assignments
● 3 infographics based on main lectures (not research lectures)
○ A3 size
○ Original figures and text
○ To summarize main content
● During tutorials, 10 minute presentations for feedback (1 total per group)
○ No grade

Exam
● 30 multiple choice
● 3 open questions
● 60 points total
● 10 MC, 1 OC per block
● Minimum 6

, Introduction
Barriers for drugs
● Intestinal enzymes
● Mucus
● Tight junctions
● Epithelial cells
● Sub epithelium

Barriers in blood
● Immune system
● Opsonization
○ Binding of opsonin proteins
○ Signal for removal

Pathways across the blood-brain barrier
a. Paracellular aqueous pathway
b. Transcellular lipophilic pathway
c. Transport proteins
d. Receptor-medaited transcytosis
e. Adsorptive transcytosis

Intracellular barriers
● Barriers from drug targeting within cells
● To avoid lysosomal degradation
○ Avoid endosome entrapment

Importance of drug targeting
● Maxmizing drug efficacy
● Limiting side effects
● Limting off-target accumulation

Protein treatments
● Massive potential
● Needs uptake
● No uptake into cell and degradation without uptake mechanism

How to improve drug arrival at site of action
● Nanomedicine
○ Loading the drug in a drug carrier
● Drug targeting
○ Modifying the drug (carrier) to control where it goes or activate drug release
● Targeting strategies with stimuli-responsive materials
○ Control release of drug by exposing drug to stimuli once it is at target site

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