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MCQ – Clinical Pharmacology 2019_20 questions and answers
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MCQ – Clinical Pharmacology 2019/20Drugs half-life is an index for:
a) the route of administration of the drug;
b) the duration of the drug effect when there is a relationship between it and plasma
concentrations;
c) time to reach steady-state plasma concentration after repeated administration;
d) determination of dose interval.
b) the duration of the drug effect when there is a relationship between it and plasma
concentrations;
Irrational ready-made drug formulations contain:
a) drugs with different half-life;
b) drugs for etiotropic and symptomatic treatment;
c) drugs with narrow therapeutic window;
d) drugs affecting different pathogenic mechanisms.
a) drugs with different half-life;
c) drugs with narrow therapeutic window;
Drug surveillance is done by:
a) spontaneous reporting;
b) observation studies;
c) family doctors;
d) population statistics.
all of them
Adverse drug reactions are the following types:
a) augmented;
b) bizarre;
c) chronic;
d) delayed
a) augmented;
b) bizarre;
d) delayed
Drugs contraindicated in the first half of pregnancy are:
a) Erythromycin;
b) sex steroids;
c) Penicillins;
d) oral anticoagulants.
a) Erythromycin;
,b) sex steroids;
d) oral anticoagulants.
For pharmacokinetics in elderly is true:
a) decreased excretion;
b) decreased metabolism;
c) decreased volume of distribution;
d) increased volume of distribution
a) decreased excretion;
b) decreased metabolism;
c) decreased volume of distribution;
Reasons for inadequate pharmaceutical availability are:
a) chronic renal failure;
b) improper use of the drug formulation;
c) bad quality of the drug substance;
d) participating in treatment.
b) improper use of the drug formulation;
c) bad quality of the drug substance;
First phase of clinical trial can be determinated as:
a) first application of a new substance to healthy volunteers;
b) first application of a new substance to patients;
c) efficacy and safety in a large number of patients;
d) post-marketing surveillance in thou-sands of patients.
a) first application of a new substance to healthy volunteers;
Monitoring of therapeutic plasma concentrations is necessary for:
a) theophyllin;
b) phenobarbital;
c) carbamazepin;
d) amoxicillin.
a) theophyllin;
b) phenobarbital;
c) carbamazepin;
Pharmacogenetic differences lead to:
a) decreased effect;
b) increased effect;
c) developement of adverse drug reactions;
d) avitaminosis.
a) decreased effect;
b) increased effect;
, c) developement of adverse drug reactions;
Placebo is:
a) allergic drug reaction;
b) drug form, without active substance;
c) method for treatment of acute pain;
d) drug tolerance
b) drug form, without active substance;
Nocebo effect is:
a) allergic drug reaction;
b) analgesic method;
c) adverse drug reaction, caused by placebo;
d) CNS depression
c) adverse drug reaction, caused by placebo;
When patient and doctor are aware of the contents of the formulation, the trial is
defined as:
a) open trial;
b) blind trial;
c) placebo trial;
d) double blind trial
a) open trial;
Binding of drugs with plasma proteins is important for:
a) half- life;
b) drugs interactions;
c) bioavailabillity;
d) the value of the pharmacological effect.
b) drugs interactions;
c) bioavailabillity;
Adverse drug reactions lead to:
a) increased pharmacological effect;
b) decreased risk of toxicity;
c) decreased efficacy of the treatment;
d) developement of unpredictable drug effects.
c) decreased efficacy of the treatment;
d) developement of unpredictable drug effects
Tobacco smoking:
a) increases drugs metabolism;
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