Aspirin is used to reduce fever and relieve mild to moderate pain from conditions such as muscle aches, toothaches, common cold, and headaches. It may also be used to reduce pain and swelling in conditions such as arthritis. Aspirin is known as a salicylate and a nonsteroidal anti-inflammatory drug...
Weak Inhibitors of COX-1 & COX-2 + Other MOA (5 to 10 fold COX-2 selective):
Nimesulide
NSAIDs which do not inhibit COX: Nefopam
, Aspirin
Nonselective Irreversible Inhibitors of COX
Mechanism of action
Prostaglandins, prostacyclin (PGI2) and thromboxane A2 (TXA2) are produced from
arachidoic acid by the enzyme cyclooxygenase which exist in a constitutive (COX – 1)
and an inducible (COX-2) Isoforms.
COX-2 normally present in minute quantities, is induced by cytokines and other signal
molecules at the sites of inflammation leading to the generation of PGs locally which
mediate many of the inflammatory changes and produce pain.
Aspirin inhibits COX irreversibly by acetylating one of its serine residues.
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