Human Embryology and Developmental Biology - Lecture 7 [Molecular Development]
Human Embryology and Developmental Biology – Lecture 3
Human Embryology and Developmental Biology – Lecture 2
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Radboud Universiteit Nijmegen (RU)
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Human embryology and developmental biology (NWIBB047C)
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Human Embryology and Developmental Biology – Lecture 1
08-02-2018
The cycle of life:
- Embryonic stage Fertilization of the oocyte birth
- Juvenile stage Growth metamorphosis larva
- Adult stage Fertile individuals reproduction
- Ageing stage Growing old physiological death
All cell movements/cleavages are highly conserved.
Animal models:
- Handy to investigate genes, processes, etc.
- Easy to breed, fast life cycle, etc.
The principles of development are highly conserved amongst the animal kingdom
(from organism to organism).
- Are able to phenocopy human diseases precisely
Examples of animal models:
- Xenopus laevis (kikker)
- Brachydanio rerio (zebrafish)
- Chicken
- C. elegans
- Drosophila Melanogaster
A blob of cells with cavity in the middle: blastocoel. The cavity appears, due to re-
organization of the blastomeres, during blastulation.
Unequal/displaced radial cleavage: above equator.
Discoidal meroblastic cleavage: on top of the yolk. (e.g. zebrafish).
Xenopus (kikker) has a holoblastic cleavage pattern.
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