Multiple Myeloma Exam With Verified Solutions Graded A+
7 views 0 purchase
Course
Health and Disease
Institution
Health And Disease
Multiple Myeloma Exam With Verified Solutions
What is Multiple Myeloma?
This is a bone marrow (B cell) cancer characterized by the proliferation of malignant plasma cells that can aggregate into tumor masses and then become distributed throughout the skeletal and organ systems resulting in multip...
multiple myeloma exam with verified solutions what
Written for
Health and Disease
All documents for this subject (39)
Seller
Follow
LectDan
Reviews received
Content preview
Multiple Myeloma Exam With Verified
Solutions
What is Multiple Myeloma?
This is a bone marrow (B cell) cancer characterized by the proliferation of malignant plasma cells that
can aggregate into tumor masses and then become distributed throughout the skeletal and organ
systems resulting in multiple organ damage.
What is a Plasma Cell?
Immune cell that develops from a B-cell
Secretes Antibodies
malignant plasma cell
Malignant plasma cells from one clone of B cells
abnormally large amounts of 1 type of immunoglobulin (usually IgG, occasionally IgA or IgM)
What are Immunoglobulins?
Antibody (Ab) proteins produced by plasma cells as part of the immune system.
Binds to foreign antigens
Released by activated B cells
IG Stucture:
4 protein chains - two longer ones ("heavy chains") & two shorter ones ("light chains") connected by
disulfide bonds into a Y-shaped structure.
Myeloma Pathogenesis
May involve chromosomal translocations (or break points), oncogene mutation, inactivation of tumor
suppressor genes.
To some degree still don't understand how this happened or what caused the mutations or
translocations
what happens after chromosomal trans location
Marrow to blood stream, circulating to lymph nodes, develop more, then return to soft tissue or
marrow.
Soft tissue sites to form plasmacytoma
Can do damage in the bones
Ineffective antibody production leads to
Damage to bone, kidneys from antibodies, plasmacytomas
epidemiology
Median Age at Dx = 70yo
Incidence: ALL RACES, ALL GEOGRAPHY
Currently incurable**
2nd most prevalent blood cancer (after NHL)
Presentation
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller LectDan. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.49. You're not tied to anything after your purchase.
