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Dyslipidemia Pharm - Cardio Exam 2
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Dyslipidemia Pharm - Cardio Exam 2
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Dyslipidemia Pharm - Cardio Exam 24 main Statin benefit groups
1. Individuals with ASCVD
2. LDL-C > 190 mg/dL
3. DM aged 40-75 with LDL 70-189 w/o ASCVD
4. Individuals without ASCVD or DM with LDL 70-189 and 10 year risk
for ASCVD > 7.5%
low intensity statins drop LDL-C by how much
<30%
moderate intensity statins drop LDL-C by how much
30-50%
high intensity statins drop LDL-C by how much
> 50%
List the low intensity doses for statin therapy
Simvastatin 10mg
Pravastatin 10-20mg
Lovastatin 20 mg
Fluvastatin 20-40 mg
List the high intensity doses for statin therapy
Atorvastatin 40-80mg
Rosuvastatin 20-40mg
, What is the mainstay of treatment for hyperlipidemia?
Statin therapy
Decrease LDL by 18-63%
Increase HDL by 5-15%
MOA of Statins or [HMG CoA Reductase Inhibitors]
Interrupt the conversion of HMG-CoA to mevalonate, the rate-limiting
step in cholesterol biosynthesis
what are statins' role in therapy
drug of choice for lowering LDL
- lowers CV events at the same rate
how are statins metabolized? what does this mean for treatment?
hepatically metabolized - require LFT monitoring and holding for
elevations
AE of statins
- Headache
- Insomnia
- Increased LFTs/CK
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