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ONS Chemotherapy Administration Questions and answers
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ONS Chemotherapy Administration Questions and answers
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ONS Chemotherapy AdministrationAdaptive immunity - correct answer-Secondary line of defense, specific immunity
adjuvant therapy - correct answer-Treatment of disease with substances that assist or
enhance the action of primary treatment (i.e. surgery or radiation).
Alkylating chemotherapy drug side effects - correct answer-myelosuppression, nausea and
vomiting, neurotoxicity, and other drug-specific effects
anthracycline (subcategory of antitumor chemotherapy drugs) examples. - correct
answer-Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
Cell-mediated Immunity - correct answer-mediated by T cells and their cytokine products. It
does not involve an antibody but rather cytotoxic T cells and helper T cells (TH1 or TH2).
Cells involved in adaptive immunity - correct answer-Lymphocytes: T Cells (cell-mediated
immunity) and B Cells (humoral immunity)
Cells involved in innate immunity - correct answer-neutrophils, monocytes, macrophages,
NK cells
chemokines - correct answer-chemotactic cytokines, and these protein molecules regulate
leukocyte migration and are key organizers of cell distribution in immune and inflammatory
responses.
combination therapy - correct answer-This therapy reduces the likelihood of drug resistance
because the different chemotherapy drugs have different mechanisms of action.
Cancer cells usually are heterogeneous; therefore, the effect of different mechanisms of
action increases the amount of cancer cells killed at one time. The efficiency seen by use of
multiple chemotherapy agents within a regimen provides a synergistic effect.
complete response - correct answer-No identifiable cancer presence through signs or
symptoms for at least one month or longer
consolidation treatment - correct answer-This treatment is done to ensure the treatment
takes effect and decreases the chance of a recurrence. This treatment is vital because
leukemic cells that are not clinically apparent, as through a CBC laboratory draw result or
bone marrow biopsy evaluation, are almost always still present to some small degree in the
bone marrow.
cytokines - correct answer-glycoprotein products of immune cells, such as lymphocytes and
macrophages. Cytokines are produced in response to T-cell activation and mediate effector
, defense functions. Cytokines (e.g., interleukins [ILs], interferon) themselves usually are not
cytotoxic.
G phase chemotherapy drug examples - correct answer-Toposomerase I inhibitors
(irinotecan, topotecan and Topoisomerate II (doxorubicin , etoposide) and Blyomycin
G phases chemotherapy specific goal(s) - correct answer-prevent development of elements
necessary for mitosis.
Humoral Immunity - correct answer-includes B lymphocytes, memory B cells, and plasma
cells that mediate humoral immunity. The result is the production of immunoglobulins, or
antibodies (Actor, 2014).
Immunotherapy Side Effects - correct answer-Gastrointestinal: Diarrhea, colitis
Pulmonary: Pneumonitis
Dermatologic: Rash, pruritus
Endocrine: Hypophysitis, hyper- or hypothyroidism
Renal: Nephritis
induction treatment of leukemia - correct answer-This phase of chemotherapy treatment (first
phase of treatment) usually is initiated in the hospital because of its potential for serious side
effects and complications from the severe, intended myelosuppression that ensues. The
goal is to achieve a complete response.
Innate immunity - correct answer-Primary line of defense, non-specific, no memory
M phase chemotherapy drug examples - correct answer-Plant alkaloids (vincristine,
vinblastine, vinorelbine) and Taxanes (paclitaxel, docetaxel)
M phase chemotherapy specific goal(s) - correct answer-prevent cell from going through
mitosis, ranging from metaphase arrest to microtubular disorganization
myeloablation therapy - correct answer-A process in which the bone marrow purposely is
obliterated through chemotherapy or radiation to prepare for peripheral blood stem cell
transplantation or bone marrow transplantation. Myeloablation often is used to treat blood
(i.e., liquid) malignancies, such as leukemia or lymphoma.
Name some alkylating chemotherapy drugs. - correct answer-Busulfan
Carboplatin
Cisplatin
Cyclophosphamide
Ifosfamide
Melphalan
Oxaliplatin
Name some antimetabolic cancer drugs. - correct answer-5-fluorouracil
Azacitidine
Capecitabine
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