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Modificación de la coagulación.d
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Modificación de la coagulación.
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UNIVERSIDAD DE MANIZALES – MEDICINA – FARMACOLOGÍA y TOXICOLOGÍA – 2023_ITALLER: FARMACOLOGÍA EN HEMOSTASIA Y COAGULACIÓN
PARTE A
Complete el siguiente cuadro con los resultados de las interacciones, indicando:
Resultado de la interacción
Si es farmacocinética o farmacodinámica
El mecanismo implicado o la explicación de la interacción
La opción de manejo
Ajo (extracto
FÁRMACOS Amiodarona Omeprazol Ibuprofeno Dalteparina
estandarizado)
Warfarina Interacción mayor, ya que se Interacción media Interacción mayor, Interacción moderada
potencia la accion de la El omeprazol mayor riesgo de aumentando el riesgo
Warfarina generando aumento potencializa el efecto sangrado de sangrado
del riesgo de complicación de la Warfarina El ibuprofenos El ajo tiene
hemorrágica, ya que las dos desplaza a la propiedades
tienen una gran union a El omeprazol al ser Warfarina hasta un anticoagulantes
proteínas y esto genera que se un inhibidor 3% de su union a
aumenta la concentración de enzimático genera proteinas generado
Warfarina libre inhibición del un amento hasta tres
metabolismo veces los niveles
Farmacodinámica hepático aumentando libres de Warfarina
el riesgo de
PKA: 5 hemorragia Farmacodinamia
Se debe mandar menos Farmacodinamia
walfarina Se debe de mandar
menos walfarina
Clopidogrel
ASA
Enoxaparina
Rivaroxabán
Alteplasa
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