Pharm Sem 2 Final Exam Questions With 100% Correct Answers.

Pharm Sem 2 Final Exam Questions With 100% Correct Answers. SSRI MOA - answerinhibition of the serotonin transporter (SERT), prevents 5-HT reuptake into the neuron when are MAOIs contraindicated? - answerbasically with all other psych meds (SSRIs, SNRIs, TCA, buspirone, 5HT2 antagonists, mirtazapine, etc) SNRIs MOA - answerinhibit the reuptake of both serotonin and NE at presynaptic neuronal membrane, leading to increased extracellular levels of both AE of venlafaxine - answerHTN at higher doses SSRI and SNRI contraindication - answeruse with serotonergic meds (triptans or certain opioids) d/t risk of serotonin syndrome TCAs MOA - answerinhibit the reuptake of both serotonin and NE at presynaptic neuronal membrane, leading to increased extracellular levels of both antagonizes H1 receptors, alpha 1 adrenergic receptors, and muscarinic acetylcholine MAOI MOA - answerinhibit MAO activity, which is responsible for the breakdown of neurotransmitters such as serotonin, NE, and dopamine increases the levels of these neurotransmitters in the brain MAOI - answeruse for treatment resistant depression/atypical depression MAOI - answeruse for social anxiety disorder dietary restrictions with MAOIs - answerpts must adhere to a tyramine restricted diet to avoid HTN crisis (ex: aged cheese, cured meats, fermented products) 5HT2 antagonists MOA - answerblock the activity of serotonin 2 receptors, modulated neurotransmission, leading to changes in mood and emotional status what else can trazadone be used for? - answerinsomnia mirtazapine MOA - answerworks by enhancing the release of serotonin and NE in the brain thru its antagonism of central presynaptic alpha 2 adrenergic autoreceptors and heteroreceptors what is special about mirtazapine? - answersedative effects and lack of sexual side effects make it preferred choice for some pts appetite stimulating effects can be beneficial in pts with unintentional weight loss or anorexia bupropion MOA - answerinhibition of reuptake of dopamine and NE smoking cessation (under name zyban) - answerbupropion brupropion CI - answerseizure disorders hx of anorexia and bulimia useful for pts that have comorbid depression and ADHD - answerbupropion vortioxetine MOA - answermultimodal antidepressant acts as serotonin modulator and stimulator what needs to be monitored with vortioxetine? - answermood, symptoms, and possible AE (sexual dysfunction, SS, hyponatremia, suicidal ideation) vilazodone MOA - answerselectively inhibits the reuptake of serotonin (5HT) into the neurons and acts as a partial agonist at serotonin 5HT1A receptors what is CI with vilazodone? - answerpts taking linezolid or methylene blue what do you need to monitor with vilazodone? - answermood, sx, and AE 1st gen antipsychotics MOA - answerantagonize dopamine D2 receptors in the brain, in mesolimbic pathway reduce dopamine neurotransmission CI of 1st gen antipsychotics - answerparkinsons, hx of neuroleptic malignant syndrome (NMS) AE of antipsychotics - answerhyperprolactinemia: resulting in menstrual irregularities, galactorrhea, and sexual dysfunction 2nd gen antipsychotics MOA - answersimilar to 1st gen but also antagonize serotonin 5- HT2A receptors in greater extent SGA can be adjunct in what? - answermood disorders such as BPD, MDD what to monitor in SGA - answerlipids, CMP lithium MOA - answermodulate neurotransmitter signaling, particularly serotonin and NE, and inhibit GSK-3, leading to neuroprotective effects