, - Ook in andere omstandigheden: beschadiging HSC, nierfalen, sportinspanning
Diagnose NSTE-ACS nooit obv enkel biomerkers – interpretatie stijging in gehele kliniek
2) Risicostratificatie bij ACS
HR: invasief beleid LR: conservatief beleid
- Hoge TIMI of GRACE-score - Pijn verdwijnt
- Hs Trop + - Geen evolutie van Trop
- Dynamische ST-T veranderingen - Geen evolutie van ECG
- DM of nierinsufficiëntie
- Recidief na voorgaand MI, PCI, CABG
3) Therapie
Anti-plaatjes aggregatie( DAPT)
- Lage dosis Salicylaat (aspirine) 75-100 mg/d Blokkade TxA2-pathway
- Clopidogrel of Ticagrelor 75 of 2x 90 mg/d Blokkade ADP-pathway
Anti-trombines
- Niet-gefractioneerde heparine
- LMWH
- Bivaluridine
- Fondaparinux
Anti-ischemische behandeling
- B-blokker PO of IV Reductie ischemie Pols 50-60/min
- Nitraten IV Reductie PL Coronaire VD
Plaque stabilisatie
- Statine Hoge dosis
- ACE-I
Coronaire interventie
- HR patiënt < 24 u
- Voorbehandeling met antiplaatjes & antitrombotica
- Diagnostische coronografie
- Resultaat Stent > ballon
4
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