, endogenous causes of tissue injury- ✅✅ tissue necrosis, enzymes
activation
immune-mediated processes
storage of substances
Proteolysis from tissue injury causes- ✅✅metabolite storage, release of
chem mediators, activation of coag. system and self-antigen formation
Storage of metabolites due to tissue injury leads to- ✅✅ acidosis,
hyperionia (K+ ), hyperosmosis
✅✅
release of chemical mediators due to tissue injury from _________,
________ and ___________ leads to :- from neural terminations,
platelets and mast cells vascular reaction
Vasodilatation and exudation stage breaks into 3 parts- ✅✅ vascular rxn
formation of the inflammatory exudate and phagocytosis
migration of neutrophils and bacterial phagocytosis
Vascular rxn of Vasodilatation and exudation stage- ✅✅ arterioles +
arteries - catecolamines cause spasm (vasoconstrict), serotonin releases
-> paralytic dilation
capillaries - stasis -> poststasis all leads to hyperemia and cap congestion
exudate vs. transudate- ✅✅ Exudate
extravascular fluid with high protein content and cellular debris (implies
increased permeability and therefore inflammation)
Transudate
extravascular fluid with low protein content, little to no cellular debris (no
increased permeability and therefore NO inflammation)
✅✅
Formation of the inflammatory exudate of Vasodilatation and exudation
stage- Hyperionia, hyperosmosis, acidosis (h20 exudate) and
Increasing of vascular permeability (serum+plasma exudate and
leukodiapedesis)
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