Metoclopramide (Maxeran) Actions (5) - ANS-increases pressure in lower esophageal sphincter
increasing peristaltic movements in the esophagus, stomach, and small intestine
increases gastric emptying
relieves N/V
Antagonizes central and peripheral dopamine receptors, raising the threshold of activity in the
chemoreceptor zone- antiemetic effects
Used to counteract the gastric states and nausea associated with migraine
Metoclopramide (Maxeran) Indications - ANS-N/V
Headache suggestive of being vascular in origin (migraine)
Metoclopramide (Maxeran) Considerations (4) - ANS-Maxeran can cause extrapyramidal
symptoms if administered to quickly:
A) Dyskinesia- repetitive, involuntary body/facial movements
B) Akathisia- extreme form of restlessness
C) Dystonia- very strong muscle contractions
Use with caution in pts with HTN, depression, parkinson's, elders (risk of dyskinesia), breast CA
Ondasteron (Zofran) Actions (2) - ANS-Is an 5-HT3 receptor antagonist
Antiemetic effects chiefly derive from a blockade of serotonin vagal afferent nerve endings in the
GI tract with some minor antagonism of medullary receptors
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