Midterm Exam: NR 568 / NR568 (Latest 2024/ 202 5 Update ) Advanced Pharmacology for the A GPCNP Complete Guide (Weeks 1-
4) Questions and Verified Answers -100% Correct - Grade A - Chamberlain Q:IPenicillins-Examples 1.INarrow-spectrumIPCNsI(penicillinase Isensitive) 2.INarrow-spectrumIpenicillins: I(penicillinase -resistant) 3.IBroad-spectrumIpenicillinsI(aminopenicillins) 4.IExtended-SpectrumIPenicillins I(Antipseudomonal IPenicillins) Answer: 1.IPenicillinIG,IPenicillinIV 2.INafcillin,IOxacillin,IDicloxacillin 3.IAmpicillin, IAmoxicillin 4.Ipiperacillin Q:IIndications IforIuseIofIPCNs 1.IPenicillinIG,IPenicillinIVI(Narrow/PCN -aseIS) 2.INafcillin,IOxacillin,IDicloxacillin I(Narrow/PCN -aseIR) 3.IAmpicillin, IAmoxicillin I(Broad) 4.Ipiperacillin I(extended) Answer: I1.streptococcal Ipharyngitis III,IN.IMeningitis/gonorrhoeae IactiveIagainstImostIgramI+/-
IcocciIandIspirochetes -T.Ipallidum 2.useIforIallIPCN-aseIRIStaphIinfectionsIie:IS.IaureusIandIS.Iepidermidis, INOTIMRSA 3.Amoxicillin -1stIlineIforIENT/Skin/UTIs Iie:IAOMIandIsinusitisIII,IAmoxicillin I+Iclavu-
IlanateIfirstIlineIforISevereIAOMI&Ianimal/human Ibites,IAmpicillin -
1stIlineIforIinfantsIwithIUTIs 4.usedImainlyIforIP.Iaeruginosa; IoftenIcombinedIwithI²lactamase IinhibitorI(Zosyn),IalsoIusedIf
orIH.Iinfluenzae, IE.Icoli,Ienterococci, IN.Igonorrhoeae, Q:IMOAIforIPCNs Answer: I•IdisruptionIofItheIbacterialIcellIwall •ItheyIareIbactericidal; IbacteriaImustIbeIactivelyIgrowingIforIthemItoIwork Q:IContraindications IandIhigh-riskIpatientsIofIPCNs 1.IWhatIisItheImainIcontraindication IinIgeneral? 2.IPenicillinIG,IPenicillinIV 3.IAmpicillin, IAmoxicillin I(Broad) 4.Ipiperacillin I(extended) Answer: I1.PCNIallergy-
IitIcanIrangeIfromIaIminorIrashItoIanaphylaxis; IitIcanIdecreaseIoverItimeIbutIifIsevereIshouldI
NOTIbeIused;IifInoIotherIalternativeIptsIcanIundergoIskinItestingIbutIthisIstillIcarriesIaIrisk 2.TheInextImostIcommonIADRIisInon-allergicIrash;IProbenecid I(antigoutImed) prolongsItheIhalf-lifeIofIPCNsIandIincreasesIriskIforItoxicity 3.rashIandIdiarrheaIareImostIcommon I 4.canIcauseIbleedingIbyIdisruptingIpltIfunction •IDosageIshouldIbeIreducedIinIpatientsIwithIrenalIimpairment Q:IMonitoring IneedsIforIPCNs 1.IMonitoring IforIrenalIimpairment IwhichIcanIcause 2.IIdentifying IHigh-RiskIPatients 3.IBaselineIdata Answer: I1.PCNsItoIaccumulate ItoItoxicIlevels.IAlsoImonitorIforIallergyIsymptomsIII,IC.diffIdiarrhea 2.Penicillins IshouldINOTIbeIusedIinIpatientsIwithIaIhistoryIofIsevereIallergicIreactionsItoIpeni
cillins,Icephalosporins, IorIcarbapenems 3.ObtainIaIculture Q:IPatient-CenteredICareIAcrossItheILifeISpan-Penicillins Infants •IPenicillinsIareIusedIsafelyIinIinfantsIwith Children/adolescents •IPenicillinsIareIaIcommonIdrugIusedItoItreat PregnantIwomen •IAlthoughIthereIareInoIwell-controlledIstudiesIinIpregnantIwomen Breastfeeding Iwomen •I(blank)IisIsafeIforIuseIinIbreastfeeding Imothers.IOlderIadults •IDosesIshouldIbeIadjustedIinIolderIadultsIwith Answer: IInfants •IbacterialIinfections,IincludingIsyphilis,Imeningitis, IandIgroupIAIstreptococcus. IChildren/adol
escents •IbacterialIinfectionsIinIchildren.IPregnantIwomen •IevidenceIweIdoIhaveIsuggestsIthereIisInoIsecondIorIthirdItrimesterIfetalIrisk.IBreastfeeding I
women •IAmoxicillin; IDataIareIlackingIregardingItransmission IofIsomeIotherIpenicillinsIfromImotherIt
oIinfantIthroughIbreastImilk. OlderIadults •IrenalIdysfunction. Q:IPatientIEducation-inIgeneral 1.IFinishingItheIPrescribedICourse Answer: IItIisIimperative IthatIantibioticsInotIbeIdiscon-
ItinuedIprematurely. IEarlyIdiscontinuation IisIaIcommonIcauseIofIrecurrentIinfection,IandItheIo
rganismsIresponsible IforIrelapseIareIlikelyItoIbeImoreIdrugIresistantIthanIthoseIpresentIwhenIt
reatmentIbegan Q:IAlternative IdrugsItoIpatientsIwithIaIhistoryIofIpenicillinIallergy Answer: I•IIfItheIallergyIisImild,IaIcephalosporin IisIoftenIanIappropriate Ialternative I •IForImanyIinfections,Ivancomycin, Ierythromycin, IandIclindamycin IareIeffectiveIandIsafeIalter
natives Q:IContraindications IandIhigh-riskIpatientsICephalosporins 1.ItheIMainIriskIwithIcephalosporins Iis 2.ICephalosporins IhaveIbeenIreportedIwithItypeIIIallergicIreactions 3.IContraindicated Ifor 4.ICautionIisIneededIifItheseIdrugsIareIcombinedIwithIotherIbleedingIagents- Answer: I1.C.IdifficileIinfection 2.serumIsickness-likeIreactions,IandIotherIskinIrashes,Iarthralgia,IandIfever 3.ptsIwithIsevereIPCNIallergyIorICephIallergy 4.(anticoags, INSAIDS,Ithrombolytic) ItheyIcanIinterfereIwithIVitIK Q:IIndications IforIuseIofICephalosporins 1.IFirst-generation-Cephalexin I(Keflex) 2.ISecondIgeneration-cefoxitinI(Mefoxin) 3.IThird-generationIcefotaxime 4.IFourthIgenerationIcefepimeI(Maxipime) 5.Iceftaroline I(Teflaro) Answer: I1.narrowIspectrum,Iskin,IsoftItissueIinfections,IusedIforIGramI+IS.IAureus/epidermidis/strepto
cocci,IusedIasIanIalternativeIinIptsIwithIaImildIPCNIallergy,IsurgicalIprophylaxis 2.broaderIspectrum,Iotitis,Isinusitis,Irespiratory Itract,IKlebsiella, IE.IcoliIGr+I/Gr- 3.moreIresistantItoI²lactamases; Imeningitis, IgramI-Inosocomial Iinfections 4.narrowIspectrum-HAPIandIresistantIpseudomonas 5.narrowIspectrum;IMRSAIinfections Q:ICephalosporins IMOA Answer: I-IdisruptIcellIwallIsynthesis -IareIbactericidal, IoftenIresistantItoI²lactamases Q:IMonitoring IneedsIforICephalosporins
