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Samenvatting Hoofdstuk 9 fysiologie cel 2
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Hoofdstuk 9 fysiologie van cel 2. Compleet met lesnotities als info uit slides.
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CEL 2: FYSIOLOGIE H9Prof. Alain Labro
Pauline Debbaut
, H9: cellulaire fysiologie: skelet-, hart-, gladde spier
- Skeletspier: dwarsgestreepte spier
o 1 cel overheen gehele spier à aan beide uiteinden contact maken
o Meer dan1 kern
o I-band (ac=ne)
o A-band (myosine) – niet gepolariseerd – anisotropen
- Moleculaire structuur van sarcomeer
o Dunne (thin) – ac=ne
o Dike (thick) – mysosine filamenten
- T-tubules: verzekeren snelle AP propaga=e
o In cel invagineren
o AP genereren over volledige plamamembraan à via T-tubuli alles bereiekn
(ook sarcomeren binnenste membraan)
o Overlapping A en I band à spiercontrac=e
- AP ac=veert L-type Ca2+
o Reorienta=e Ca kanaal à Ca influx
o 4 ca kanalen gekoppeld aan 1 RyR
à reorienta=e opent RyR rechtstreeks
è AP in spier = exicta=e-contrac=e koppeling
- Types RyR:
o 1: skeletspier
§ Directe communica=e
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