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NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS MIDTERM AND FINAL EXAM STUDY GUIDE| 300 QUESTIONS AND 100 % CORRECT ANSWERS | RATED A QUIZ BANK | LATEST, 2024 / 2025| CHAMBERLAIN COLLEGE$25.99
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NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS MIDTERM AND FINAL EXAM STUDY GUIDE| 300 QUESTIONS AND 100 % CORRECT ANSWERS | RATED A QUIZ BANK | LATEST, 2024 / 2025| CHAMBERLAIN COLLEGE
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NR565 ADVANCED PHARMACOLOGY
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NR565 ADVANCED PHARMACOLOGY
NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS
MIDTERM AND FINAL EXAM STUDY GUIDE| 300 QUESTIONS
AND 100 % CORRECT ANSWERS | RATED A QUIZ BANK |
LATEST, 2024 / 2025| CHAMBERLAIN COLLEGE
1 | P a g e NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS MIDT ERM AND FINAL EXAM STUDY GUIDE| 300 QUESTIONS AND 100 % CORRECT ANSWERS | RATED A QUIZ BANK | LATEST, | CHAMBERLAIN COLLEGE The process by which drugs are absorbed, distributed within the body, metabolized, and excreted. - CORRECT ANSWER >>>Pharmacokinetics The study of what the drug does to the body - CORRECT ANSWER >>>Pharmacodynamics Rate of dissolution Surface area Blood fl ow Lipid solubility pH partitioning - CORRECT ANSWER >>>Factors Affecting Drug Absorption 2 | P a g e Blood flow to tissues Ability to exit the vascular system Blood -brain barrier Protein -binding capacity - CORRECT ANSWER >>>Factors Affecting Drug Distribution subst ances that are foreign to the body, usually synthetic chemical compounds; medications are a common example - CORRECT ANSWER >>>Xenobiotics xenobiotic -metabolizing enzymes necessary for the production of cholesterol and steroids and the detoxification of chemicals and drug metabolism. - CORRECT ANSWER >>>Cytochrome P450 (CYP450) responsible for phase 1 metabolism in which drugs are oxidized, reduced, or hydrolyzed - CORRECT ANSWER >>>Function of Cytochrome P450 (CYP450) Oxidation; Reduction; Hydrolysis - CORRECT ANSWER >>>Phase 1 Metabolism of Drugs via P450 -Drug becomes completely inactive -Drug becomes partially inactive but one or more metabolites remain active 3 | P a g e -Original drug is not pharmacologically active but one metabolite remains active - CORRECT ANSWER >>>Three possible outcomes of phase 1 drug metabolism. Medications that can increase the rate of another drug's metabolism by elev ating CYP450 enzyme activity via increasing enzyme synthesis. decreasing the concentration of the "parent drug" - CORRECT ANSWER >>>CYP450 Inducers CRAPGPS Carbamazepine Rifampin Alcohol Phenytoin Griseofulvin Phenobarbital Sulfonylureas - CORRECT ANSWER >>>CYP450 Inducer Medications Medications that inhibit the metabolic activity of one or more of the CYP450 enzymes. Higher risk for toxicity; prolongs the pharmacological effect of the "parent drug". - CORRECT ANSWER >>>CYP450 Inhibitors VISACKGQ Valproa te Isoniazid Sulfonamides Amiodarone 4 | P a g e Chloramphenicol Ketoconazole Grapefruit Juice Quinidine - CORRECT ANSWER >>>CYP450 Inhibitor Medications -potentially Inappropriate Medication (PIM) use in older adults -potentially Inappropriate Medication (PIM) use in older adults due to medication -disease or medication -syndrome interactions that may exacerbate the disease or syndrome -medications to be used cautiously in older adults -clinically significant drug intera ctions that should be avoided in older adults -medications to be avoided or dosage decreased in the presence of impaired kidney function in older adults - CORRECT ANSWER >>>Beers Criteria when one medication systemically alters the potency of another medi cation. - CORRECT ANSWER >>>Pharmacokinetic Interactions result of a change due to one medication's effect on another medication's route of entry into the body. - CORRECT ANSWER >>>Absorption Interaction caused by the amount of unbound/free medications a vailable at the various target sites. - CORRECT ANSWER >>>Distribution Interaction
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