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Samenvatting deel 'fysiologie van de verslaving' - Celbiologie partim fysiologie $7.69
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Samenvatting deel 'fysiologie van de verslaving' - Celbiologie partim fysiologie

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Samenvatting van het vak 'celbiologie partim fysiologie - Fysiologie van de vereslaving' gegeven door F. Lardon & A. Wouters in de 1ste Bachelor Geneeskunde aan de UA. Volledige samenvatting gebaseerd op college slides, eigen lesnotities én handboek.

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  • August 1, 2024
  • 6
  • 2022/2023
  • Summary
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FYSIOLOGIE VAN DE VERSLAVING

1. Wat is verslaving

I. Verslaving
= neurobiologische aandoening (geneesbaar)

= progressieve aandoening

= ontwikkelingsstoornis

= (multi)genetische en/of omgevingsaandoening

= multiple pathways → heterogeen fenotype

⇒ moeilijk, maar behandelbaar

termen
● afhankelijkheid
● misbruik
● verslaving
● verslavende stoffen


II. Verslavende stoffen
= stoffen met een belonend karakter die een goed/aangenaam gevoel geven
→ euforie

= stoffen waar mensen, eenmaal ze gehad te hebben, bij voortduring aan moeten denken
→ craving

= stoffen waar sommige mensen, eenmaal ze te kennen, niet vanaf kunnen blijven
→ controleverlies → afhankelijkheid

, 2. Neurotransmissie

I. Vrijstelling van neurotransmitters
→ bv. peptiden, purines, gassen, lipiden

acetylcholine (ACh)
● choline + acetyl CoA → ACh
● cholinerge neuronen
● cholinerge receptoren
● agonist: nicotine
○ maakt je rustig
○ produceert secundaire neurotransmitters: dopamine
● antagonist: curare
○ spierzwakte

(catechol)amines
● tyrosine
○ (nor)epinephrine = (nor)adrenaline
○ dopamine
● tryptofaan → serotonine
● histadine → histamine
● (nor)adrenerge neuronen
● (nor)adrenerge receptoren (𝛼, 𝛽)

aminozuren (CZS)
● exciterende neurotransmitters
→ depolariseren
● inhiberende neurotransmitters
→ hyperpolariseren
● GABA → gevoel van kalmte
● glycine
● glutamaat


II. Einde van neurotransmissie
● heropname in axonen of gliacellen
● diffusie uit synaptische spleet
● enzymatische afbraak
→ bv. acetylcholinesterase (AChE)

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