PHARMACOLOGYPROCTOREDEXAM/RN
PHARMACOLOGYATIPROCTOREDACTUALEXAMTEST
BANK200QUESTIONSANDCORRECTDETAILED
ANSWERSWITHRATIONALES|ALREADYGRADEDA+
Whatarethemajorfunctionsoftheα1receptor?
-correctanswer-Increasevascularsmoothmusclecontraction,increase
pupillarydilatormusclecontraction(mydriasis),increaseintestinaland
bladdersphinctermusclecontractionWhatarethemajorfunctionsof
theα2receptor?
-correctanswer-Decreasesympatheticoutflow,decreaseinsulin
release,decreaselipolysis,increaseplateletaggregation,decrease
aqueoushumorproductionWhatarethemajorfunctionsoftheβ1
receptor?
-correctanswer-Increaseheartrate,increasecontractility,increase
reninrelease,increaselipolysisWhatarethemajorfunctionsoftheβ2
receptor?
-correctanswer-Vasodilation,bronchodilation,increaselipolysis,
increaseinsulinrelease,decreaseuterinetone(tocolysis),ciliarymuscle relaxation,increaseaqueoushumorproductionWhatarethemajor
functionsoftheM1receptor?
-correctanswer-CNS,entericnervoussystemWhatarethemajor
functionsoftheM2receptor?
-correctanswer-DecreaseheartrateandcontractilityofatriaWhatare
themajorfunctionsoftheM3receptor?
-correctanswer-Increaseexocrineglandsecretions(e.g.,lacrimal,
salivary,gastricacid),increasegutperistalsis,increasebladder
contraction,increasebronchoconstriction,pupillarysphinctermuscle
contraction(miosis),ciliarymusclecontraction(accommodation)What
arethemajorfunctionsoftheD1receptor?
-correctanswer-RelaxesrenalvascularsmoothmuscleWhatarethe
majorfunctionsoftheD2receptor?
-correctanswer-Modulatestransmitterrelease,especiallyinthebrain
WhatarethemajorfunctionsoftheH1receptor?
-correctanswer-Increasenasalandbronchialmucusproduction,
increasevascularpermeability,contractionofbronchioles,pruritis,pain
WhatarethemajorfunctionsoftheH2receptor?
-correctanswer-IncreasegastricacidsecretionWhatarethemajor
functionsoftheV1receptor?
-correctanswer-IncreasevascularsmoothmusclecontractionWhatare
themajorfunctionsoftheV2receptor? -correctanswer-IncreaseH2Opermeabilityandreabsorptionin
collectingtubulesofkidney(V2isfoundinthe"2"kidneys)What
receptorsareassociatewithGq?
-correctanswer-H1,α1,V1,M1,andM3Whatreceptorsareassociated
withGs?
-correctanswer-H2,B1,B2,V2,D1Whatreceptorsareassociatedwith
Gi?
-correctanswer-M2,α2,D2Bethanechol
-correctanswer--Directcholinergicagonist-Activatesboweland
bladdersmoothmuscle-Usedinpostoperativeandneurogenicileus-
ResistanttoAChECarbachol
-correctanswer--Directcholinergicagonist-Carboncopyof
acetylcholine-Constrictspupilsandrelievesintraocularpressurein
glaucomaMethacholine
-correctanswer--Directcholinergicagonist-Stimulatesmuscarinic
receptorsinairwayswheninhaled-Usedasachallengetestfor
diagnosisofasthmaPilocarpine
-correctanswer--Directcholinergicagonist-Contractsciliarymuscleof
eye(openangleglaucoma),contractspupillarysphincter(closedangle
glaucoma)-Potentstimulatorofsweat,tearsandsaliva-AChEresistant
Donepezil
-correctanswer--Anticholinesterse-increasesACh-Alzheimerdisease Galantamine
-correctanswer--Anticholinesterse-increasesACh-Alzheimerdisease
Rivastigmine
-correctanswer--Anticholinesterse-increasesACh-Alzheimerdisease
Edrophonium
-correctanswer--Anticholinesterse-increasesACh-Historicallyused
todiagnosemyastheniagravis(MGisnowdiagnosedbyanti-AChRAb
test.Neostigmine
-correctanswer--Anticholinesterse-increasesACh-Usedin
postoperativeandneurogenicileusandurinaryretention,myasthenia
gravis,andpostoperativereversalofneuromuscularjunctionblockade
Physostigmine
-correctanswer--Anticholinesterse-increasesACh-Usedin
anticholinergictoxicity-Crossestheblood-brainbarrier(CNS)
Pyridostigmine
-correctanswer--Anticholinesterse-increasesACh-Increasesmuscle
strength-Usedinmyastheniagravis(longacting)-Doesnotpenetrate
CNSAtropine
-correctanswer--Muscarinicantagonist-Usedinbradycardiaandfor
ophthalmicapplications-Alsousedasantidoteforcholinesterase
inhibitorpoisoning-Actionsincludeincreasepupildilation,cycloplegia,
decreasedairwaysecretions,decreasedacidsecretions,decreasedgut
